1449426-94-1Relevant articles and documents
Developments in Meyers' lactamization methodology: En route to Bi(hetero)aryl structures with defined axial chirality
Postikova, Svetlana,Sabbah, Mohamad,Wightman, Daniel,Nguyen, Ich Tuan,Sanselme, Morgane,Besson, Thierry,Briere, Jean-Francois,Oudeyer, Sylvain,Levacher, Vincent
supporting information, p. 8191 - 8197 (2013/09/12)
Highly atroposelective Meyers' lactamization promoted by pivalic acid under microwave irradiation is reported which allows the construction of nonracemic substituted-dibenzo(di)azepine derivatives through a center to axial chirality transfer principle, controlling the otherwise configurationally labile biaryl axis. This approach provides a straightforward entry to enantioenriched analogues of biorelevant architectures.