1449432-43-2Relevant articles and documents
Synthesis and antitumor activity of des-AB analogue of steroidal saponin OSW-1
Minato, Daishiro,Li, Bozhi,Zhou, Dejun,Shigeta, Yasumi,Toyooka, Naoki,Sakurai, Hiroaki,Sugimoto, Kenji,Nemoto, Hideo,Matsuya, Yuji
, p. 8019 - 8024 (2013)
Simplified des-AB-type aglycone of antitumor steroidal saponin OSW-1 was concisely prepared starting from readily available Hajos ketone. We further completed the synthesis of des-AB-OSW-1 analogue by the installation of the disaccharide moiety into the des-AB aglycone, and evaluated its antitumor activity. The results indicated that a truncated aglycone drug design strategy based on OSW-1 would be a promising approach for the development of novel antitumor agents.