144991-37-7

Basic information

• Product Name: 1H-Pyrazol-5-amine,1-(2-methoxyethyl)-(9CI)
• Synonyms: 1H-Pyrazol-5-amine,1-(2-methoxyethyl)-(9CI)
• CAS NO: 144991-37-7
• Molecular Formula: C6H11N3O
• Molecular Weight: 141.17104
• Product Categories: VARIOUSAMINE
• Mol File: 144991-37-7.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1H-Pyrazol-5-amine,1-(2-methoxyethyl)-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrazol-5-amine,1-(2-methoxyethyl)-(9CI)(144991-37-7)
• EPA Substance Registry System: 1H-Pyrazol-5-amine,1-(2-methoxyethyl)-(9CI)(144991-37-7)

Safety Data

• Hazardous Substances Data: 144991-37-7(Hazardous Substances Data)

Usage

Molecular weight

150.17 g/mol

Chemical class

Pyrazole

Common uses

Building block for the synthesis of biologically active compounds, intermediate in the production of dyes, pigments, and other chemical products

Known for

Diverse reactivity and potential applications in chemical research and development.

Upstream product

• 126352-83-8 1-(2-methylsulfonyloxyethyl)-4-ethoxycarbonyl-5-aminopyrazole 
• 58046-49-4 5-amino-4-ethoxycarbonyl-1-(2'-hydroxyethyl)-pyrazole 
• 144991-36-6 5-Amino-1-(2-methoxy-ethyl)-1H-pyrazole-4-carboxylic acid 

Relevant articles and documents

Studies on 3'-quaternary ammonium cephalosporins-IV. Synthesis and antibacterial activity of 3'-(2-alkyl-3-aminopyrazolium)cephalosporins related to FK037

The synthesis and in vitro antibacterial activity of 7β-[(Z)-2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido] cephalosporins bearing various 2-alkyl-3-aminopyrazolium groups at the 3-position are described. Antibacterial activity against MRSA was affected by the nature of the substituent at the 2-position on the 3'-aminopyrazolium groups. Among the cephalosporins prepared in this study, 7β-[(Z)-2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido]-3-[3-amino-2-(2 -hydroxyethyl)-pyrazolio]methyl-3-cephem-4-carboxylate sulfate (23e, FK037) showed extremely potent broad-spectrum activity against both Gram-positive bacteria including MRSA, and Gram-negative bacteria including Pseudomonas aeruginosa. In particular, the in vivo activity against MRSA of FK037 was the highest of all the β-lactam antibiotics tested.