145080-95-1 Usage
General Description
(S)-(-)-2-ISOCYANATOGLUTARIC ACID DIETHYL ESTER is a chemical compound characterized by the presence of an isocyanate functional group. It is a diethyl ester derivative of isocyanatoglutaric acid, and it is commonly used as an intermediate in the synthesis of various organic compounds. This chemical is often utilized in the production of polymers, adhesives, and coatings, as well as in the manufacturing of pharmaceuticals and agrochemicals. It possesses valuable reactivity and properties that make it useful in a variety of industrial applications. Additionally, (S)-(-)-2-ISOCYANATOGLUTARIC ACID DIETHYL ESTER has the potential for further research and development in the field of organic chemistry due to its unique structure and functional groups.
Check Digit Verification of cas no
The CAS Registry Mumber 145080-95-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,5,0,8 and 0 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 145080-95:
(8*1)+(7*4)+(6*5)+(5*0)+(4*8)+(3*0)+(2*9)+(1*5)=121
121 % 10 = 1
So 145080-95-1 is a valid CAS Registry Number.
InChI:InChI=1/C10H15NO5/c1-3-15-9(13)6-5-8(11-7-12)10(14)16-4-2/h8H,3-6H2,1-2H3/t8-/m0/s1
145080-95-1Relevant articles and documents
Synthesis process of Raltitrexed key intermediate
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Paragraph 0047-0051, (2019/05/22)
The invention relates to the technical field of medicine preparation, in particular to a synthesis process of a Raltitrexed key intermediate. According to the synthesis process of the Raltitrexed keyintermediate, forming an active intermediate (isocyanate) through glutamate diethyl ester, the active intermediate and N-methyl-(2-thienyl) tert-butyl carbamate are directly reacted, and a target product N-[5-[N-(t-butyloxycarboryl)-N-methyl amino]-2-thenoyl]-L-glutamate diethyl ester is prepared by two steps. The synthesis process avoids difficulties of potential risks of part of racemization ofa chiral center caused by amidation reaction, low yield, complicated operation and purification and the like. The synthesis process of the Raltitrexed key intermediate is simple to operate, short in line, environmentally friendly and high in yield.