1451073-56-5Relevant articles and documents
Acid-cleavable thiomaleamic acid linker for homogeneous antibody-drug conjugation
Castaneda, Lourdes,Maruani, Antoine,Schumacher, Felix F.,Miranda, Enrique,Chudasama, Vijay,Chester, Kerry A.,Baker, James R.,Smith, Mark E. B.,Caddick, Stephen
supporting information, p. 8187 - 8189 (2013/09/12)
In this communication we describe a novel acid-cleavable linker strategy for antibody-drug conjugation. Functional disulfide bridging of the single interchain disulfide bond of a trastuzumab Fab fragment yields a homogeneous antibody-drug conjugate bearin