1451181-01-3Relevant articles and documents
Chemical synthesis of highly congested gp120 V1V2 N -glycopeptide antigens for potential HIV-1-directed vaccines
Aussedat, Baptiste,Vohra, Yusuf,Park, Peter K.,Fernandez-Tejada, Alberto,Alam, S. Munir,Dennison, S. Moses,Jaeger, Frederick H.,Anasti, Kara,Stewart, Shelley,Blinn, Julie H.,Liao, Hua-Xin,Sodroski, Joseph G.,Haynes, Barton F.,Danishefsky, Samuel J.
supporting information, p. 13113 - 13120 (2013/09/24)
Critical to the search for an effective HIV-1 vaccine is the development of immunogens capable of inducing broadly neutralizing antibodies (BnAbs). A key first step in this process is to design immunogens that can be recognized by known BnAbs. The monoclonal antibody PG9 is a BnAb that neutralizes diverse strains of HIV-1 by targeting a conserved carbohydrate-protein epitope in the variable 1 and 2 (V1V2) region of the viral envelope. Important for recognition are two closely spaced N-glycans at Asn160 and Asn156. Glycopeptides containing this synthetically challenging bis-N-glycosylated motif were prepared by convergent assembly, and were shown to be antigenic for PG9. Synthetic glycopeptides such as these may be useful for the development of HIV-1 vaccines based on the envelope V1V2 BnAb epitope.
