145274-93-7 Usage
Description
(D-TYR1,N-ME-PHE3)-NEUROPEPTIDE FF, a member of the neuropeptide FF family, is a chemical compound that serves a crucial role in modulating various physiological functions in the body. It is involved in the regulation of pain perception, cardiovascular regulation, and stress response, making it a subject of interest for potential therapeutic applications.
Uses
Used in Pharmaceutical Industry:
(D-TYR1,N-ME-PHE3)-NEUROPEPTIDE FF is used as a therapeutic agent for the treatment of pain and mood disorders. Its application is based on its ability to interact with specific receptors in the brain and other tissues, which leads to the modulation of neurotransmitter release and neuronal activity. This interaction has shown potential in alleviating pain and managing mood-related conditions.
Used in Research and Development:
In the field of research and development, (D-TYR1,N-ME-PHE3)-NEUROPEPTIDE FF is utilized as a subject of study to better understand its role in the body and its potential as a target for drug development. (D-TYR1,N-ME-PHE3)-NEUROPEPTIDE FF's mechanism of action and its effects on physiological functions are of particular interest to researchers, who aim to harness its properties for the development of novel therapeutic strategies.
Used in Neurological Applications:
(D-TYR1,N-ME-PHE3)-NEUROPEPTIDE FF is also used in the study and treatment of neurological conditions, given its involvement in pain perception and stress response. Its potential applications in this field may include the development of treatments for chronic pain, anxiety, and other stress-related disorders, as well as the investigation of its role in the central nervous system.
Check Digit Verification of cas no
The CAS Registry Mumber 145274-93-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,5,2,7 and 4 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 145274-93:
(8*1)+(7*4)+(6*5)+(5*2)+(4*7)+(3*4)+(2*9)+(1*3)=137
137 % 10 = 7
So 145274-93-7 is a valid CAS Registry Number.
145274-93-7Relevant articles and documents
Structure-activity study of neuropeptide FF: Contribution of N-terminal regions to affinity and activity
Gicquel,Mazarguil,Desprat,Allard,Devillers,Simonnet,Zajac
, p. 3477 - 3481 (1994)
Twenty neuropeptide FF (NPFF) analogs having various lengths were synthesized by solid-phase peptide synthesis to gain more information on the role of N-terminal residues for the NPFF receptor affinity. The affinities were evaluated in the rat spinal cord membrane preparations, and the biological activities were measured on morphine analgesia in the mouse tail- flick test. Shortening of the NPFF sequence from the N-terminus produced only a moderate decrease in affinity until NPFF(4-8) was reached. In the same way, NPFF(3-8) significantly decreased morphine analgesia, while NPFF(4-8) had no significant effect at a dose of 22 nmol. The introduction in the N-terminal part of NPFF of a D-enantiomer at positions 2 and 1 or the presence of an N- methyl group on position 3 did not modify affinity and activity. Substitution of proline5 by the D-isomer decreased the affinity of NPFF analogs whatever their length, and [Tyr1,D-Pro5]NPFF(1-8) was 2.5-fold less potent than [Tyr1]NPFF(1-8) in reversing morphine-induced analgesia. In contrast, the presence of a glycine residue in position 5 did not influence the affinity toward NPFF receptors. Data provide evidence that the N-terminal segment of neuropeptide FF is responsible for high-affinity binding.
