1452806-89-1

Basic information

• Product Name: 2-(4-(3-(1H-indol-3-yl)propyl)piperazin-1-yl)-Ncyclohexyl-N-(2-methoxyphenyl)acetamide
• CAS NO: 1452806-89-1
• Molecular Weight: 488.673
• Mol File: 1452806-89-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(4-(3-(1H-indol-3-yl)propyl)piperazin-1-yl)-Ncyclohexyl-N-(2-methoxyphenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-(3-(1H-indol-3-yl)propyl)piperazin-1-yl)-Ncyclohexyl-N-(2-methoxyphenyl)acetamide(1452806-89-1)
• EPA Substance Registry System: 2-(4-(3-(1H-indol-3-yl)propyl)piperazin-1-yl)-Ncyclohexyl-N-(2-methoxyphenyl)acetamide(1452806-89-1)

Safety Data

• Hazardous Substances Data: 1452806-89-1(Hazardous Substances Data)

Upstream product

• 3569-21-9 1H-indole-3-propanol 
• 110-87-2 3,4-dihydro-2H-pyran 
• 1452806-99-3 C₂₄H₃₇N₃O₄ 
• 1452806-96-0 2-chloro-N-cyclohexyl-N-phenylacetamide 
• 850570-34-2 N-(cyclohexylamino)-o-anisidine 
• 100-63-0 phenylhydrazine 

Relevant articles and documents

Design, synthesis, and evaluation of indolebutylamines as a novel class of selective dopamine D3 receptor ligands

A series of indolebutylamine derivatives were designed, synthesized, and evaluated as a novel class of selective ligands for the dopamine 3 receptor. The most potent compound 11q binds to dopamine 3 receptor with a Ki value of 124 nm and displays excellent selectivity over the dopamine 1 receptor and dopamine 2 receptor. Investigation based on structural information indicates that site S182 located in extracellular loop 2 may account for high selectivity of compounds. Interaction models of the dopamine 3 receptor-11q complex and structure-activity relationships were discussed by integrating all available experimental and computational data with the eventual aim to discover potent and selective ligands to dopamine 3 receptor.