1452841-05-2Relevant articles and documents
Asymmetric organocatalytic 1,4-addition reactions starting from enals with gem-difluoroalkyl side chains
Khalaf, Ali,Gree, Danielle,Abdallah, Hassan,Jaber, Nada,Hachem, Ali,Gree, Rene
, p. 653 - 657 (2013)
gem-Difluoroenals are excellent substrates for asymmetric organocatalytic 1,4-additions of thiols and anilines. By using diarylsilylprolinol ether as a catalyst, good to excellent yields with ee values in the same range (up to 98 %) were obtained. The CF2R group strongly activates the enals towards these organocatalytic additions. New chiral β-thio and β-amino aldehydes with CF2R chains can be obtained in high yields with high ee values by asymmetric organocatalytic processes after selection of the appropriate catalyst and optimization of the reaction conditions. Copyright