1453105-23-1

Basic information

• Product Name: 2-(1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-yl)acetic acid [(4-fluorophenyl)methylene]hydrazide
• CAS NO: 1453105-23-1
• Molecular Weight: 407.488
• Mol File: 1453105-23-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-yl)acetic acid [(4-fluorophenyl)methylene]hydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-yl)acetic acid [(4-fluorophenyl)methylene]hydrazide(1453105-23-1)
• EPA Substance Registry System: 2-(1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-yl)acetic acid [(4-fluorophenyl)methylene]hydrazide(1453105-23-1)

Safety Data

• Hazardous Substances Data: 1453105-23-1(Hazardous Substances Data)

Upstream product

• 946848-58-4 (R,S)-2-(1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-yl)acetohydrazide 
• 459-57-4 4-fluorobenzaldehyde 
• 122188-02-7 methyl 1,8-diethyl-1,3,4,9-tetrahydropyrano(3,4-b)-indole-1-acetate 

Downstream Products

• 1453105-36-6 SGK₂₁₆ 

Relevant articles and documents

Synthesis, cytotoxicity, and pro-apoptosis activity of etodolac hydrazide derivatives as anticancer agents

Etodolac hydrazide and a novel series of etodolac hydrazide-hydrazones 3-15 and etodolac 4-thiazolidinones 16-26 were synthesized in this study. The structures of the new compounds were determined by spectral (FT-IR, 1H NMR, 13C NMR, HREI-MS) methods. Some selected compounds were determined at one dose toward the full panel of 60 human cancer cell lines by the National Cancer Institute (NCI, Bethesda, USA). 2-(1,8-Diethyl-1,3,4,9- tetrahydropyrano[3,4-b]indole-1-yl)acetic acid[(4-chlorophenyl)methylene] hydrazide 9 demonstrated the most marked effect on the prostate cancer cell line PC-3, with 58.24% growth inhibition at 10-5 M (10 μM). Using the MTT colorimetric method, compound 9 was evaluated in vitro against the prostate cell line PC-3 and the rat fibroblast cell line L-929, for cell viability and growth inhibition at different doses. Compound 9 exhibited anticancer activity with an IC50 value of 54 μM (22.842 μg/mL) against the PC-3 cells and did not display any cytotoxicity toward the L-929 rat fibroblasts, compared to etodolac. In addition, this compound was evaluated for caspase-3 and Bcl-2 activation in the apoptosis pathway, which plays a key role in the treatment of cancer. Etodolac hydrazide and a novel series of etodolac hydrazide-hydrazones 3-15 and etodolac 4-thiazolidinones 16-26 were synthesized. 2-(1,8-Diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-yl)acetic acid[(4-chlorophenyl)methylene]hydrazide 9 demonstrated the most marked cell viability and growth inhibition effects. It was evaluated for caspase-3 and Bcl-2 activation in the apoptosis pathway. Copyright