14533-84-7

Basic information

• Product Name: PENTAFLUOROPHENYL TRIFLUOROACETATE
• Synonyms: PFP-O-TFA;PENTAFLUOROPHENYL TRIFLUOROACETATE;PENTAFLUORPHENYL TRIFLUORACETATE;TRIFLUORO ACETIC ACID PENTAFLUORO PHENYL ESTER;TFA-OPFP;Pentafluoropfenyl Trifluoroacetate;perfluorophenyl 2,2,2-trifluoroacetate;Pentafluorophenyl trifluoroacetate,Trifluoroacetic acid pentafluorophenyl ester
• CAS NO: 14533-84-7
• Molecular Formula: C₈F₈O₂
• Molecular Weight: 280.07
• EINECS: 212-235-8
• Mol File: 14533-84-7.mol
• Article Data: 2

Chemical Properties

• Melting Point: 4°C(lit.)
• Boiling Point: 122-123 °C(lit.)
• Flash Point: 126 °F
• Appearance: Clear colorless/Oil
• Density: 1.63 g/mL at 25 °C(lit.)
• Refractive Index: n20/D 1.368(lit.)
• Storage Temp.: Store at RT.
• Water Solubility: Soluble in water at 122.5°Cat760mmHg.
• Sensitive: Moisture Sensitive
• BRN: 2003848
• CAS DataBase Reference: PENTAFLUOROPHENYL TRIFLUOROACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: PENTAFLUOROPHENYL TRIFLUOROACETATE(14533-84-7)
• EPA Substance Registry System: PENTAFLUOROPHENYL TRIFLUOROACETATE(14533-84-7)

Safety Data

• Hazard Codes: Xi,F
• Statements: 10-36/37/38
• Safety Statements: 16-26-36
• RIDADR: UN 3272 3/PG 3
• WGK Germany: 3
• HazardClass: 3.2
• PackingGroup: III
• Hazardous Substances Data: 14533-84-7(Hazardous Substances Data)

Usage

Description

PENTAFLUOROPHENYL TRIFLUOROACETATE is a clear colorless liquid that serves as a versatile reagent in various chemical and pharmaceutical applications due to its unique properties.

Uses

Used in Pharmaceutical Industry:
PENTAFLUOROPHENYL TRIFLUOROACETATE is used as a pharmaceutical intermediate for its ability to facilitate various chemical reactions and syntheses in the development of pharmaceutical compounds.
Used in Dye Esterification:
PENTAFLUOROPHENYL TRIFLUOROACETATE is used as an acylating agent for the esterification of 2′-carboxyrhodamine dye to form pentafluorophenyl ester as a single isomer, which is crucial for the production of specific dyes with desired properties.
Used in Peptide Synthesis:
PENTAFLUOROPHENYL TRIFLUOROACETATE is used as a coupling agent for the peptide-type coupling of N-substituted glycine oligomers, enabling the formation of complex peptide structures with potential applications in drug development and research.
Used in Synthesis of Pentafluorophenyl Thiophene-3-Acetate (PFPTA):
PENTAFLUOROPHENYL TRIFLUOROACETATE is used in the synthesis of pentafluorophenyl thiophene-3-acetate (PFPTA) by reacting with 3-thiopheneacetic acid, which is an important intermediate in the production of various chemical compounds and materials.

Upstream product

• 771-61-9 2,3,4,5,6-pentafluorophenol 
• 407-25-0 trifluoroacetic anhydride 
• 354-32-5 trifluoracetyl chloride 

Downstream Products

• 182251-52-1 (2R,3R,4S)-3-acetylamino-4-(tert-butoxycarbonylamino)-3,4-dihydro-2H-pyran-2,6-dicarboxylic acid 6-benzhydryl ester 2-(2,3,4,5,6-pentafluoro-phenyl) ester 
• 179727-62-9 2-(2,2,2-Trifluoro-acetylamino)-benzoic acid pentafluorophenyl ester 
• 369379-70-4 1-(9H-fluoren-9-ylmethoxycarbonylamino)-pyrrolidine-2-carboxylic acid pentafluorophenyl ester 
• 369379-72-6 4-(3-benzoyl-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-pyrrolidine-1,2-dicarboxylic acid 2-(9H-fluoren-9-ylmethyl) ester 1-pentafluorophenyl ester 
• 174487-68-4 Pentafluorophenyl 4-{N-[(6S/6R)-2-methyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl]-N-(propyl-2-ynyl)amino}benzoate 
• 386252-91-1 pyridine-2,5-dicarboxylic acid dipentafluorophenylester 
• 386252-92-2 pyrazine-2,5-dicarboxylic acid dipentafluorophenyl ester 

Relevant articles and documents

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