145354-78-5 Usage
Description
((2S,4S,4'R)-2',2'-DIMETHYL-[4,4']BI[[1,3]DIOXOLANYL]-2-YL)-METHANOL is a complex organic compound characterized by its unique stereochemistry and structural features. It is a chiral molecule with specific stereodescriptors (2S,4S,4'R) and is composed of a bi-dioxolane ring system with a methyl group at the 2' and 2'' positions. ((2S,4S,4'R)-2',2'-DIMETHYL-[4,4']BI[[1,3]DIOXOLANYL]-2-YL)-METHANOL serves as a crucial intermediate in the synthesis of various pharmaceuticals due to its unique structural properties and reactivity.
Uses
Used in Pharmaceutical Industry:
((2S,4S,4'R)-2',2'-DIMETHYL-[4,4']BI[[1,3]DIOXOLANYL]-2-YL)-METHANOL is used as a key intermediate in the synthesis of Troxacitabine (T805580), a nucleoside analogue with potential anticancer activity. Troxacitabine has been studied in patients with refractory lymphoproliferative diseases, demonstrating its importance in the development of novel therapeutics for cancer treatment.
In the synthesis of Troxacitabine, ((2S,4S,4'R)-2',2'-DIMETHYL-[4,4']BI[[1,3]DIOXOLANYL]-2-YL)-METHANOL plays a critical role in the formation of the final product, which has shown promise in the treatment of various types of cancer. Its unique structural features and reactivity make it a valuable component in the development of new pharmaceuticals, particularly in the field of oncology.
Check Digit Verification of cas no
The CAS Registry Mumber 145354-78-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,5,3,5 and 4 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 145354-78:
(8*1)+(7*4)+(6*5)+(5*3)+(4*5)+(3*4)+(2*7)+(1*8)=135
135 % 10 = 5
So 145354-78-5 is a valid CAS Registry Number.
145354-78-5Relevant articles and documents
Potent Anti-HIV and Anti-HBV Activities of (-)-L-&β-Dioxolane-C and (+)-L-&β-Dioxolane-T and Their Asymmetric Syntheses.
Kim, Hea O.,Shanmuganathan, Kirupathevy,Alves, Antonio J.,Jeong, Lak S.,Beach, J. Warren,et al.
, p. 6899 - 6902 (1992)
The asymmetric syntheses of (+)-L-β-dioxolane-T and (-)-L-β-dioxolane-C were accomplished starting from 1,6-anhydro-L-β-gulopyranose, and their anti-HIV and anti-HBV activities were evaluated in human PBM cells, CEM cells and 2.2.15 cells, respectively. K
