145363-63-9

Basic information

• Product Name: 4-CHLORO-2-METHYL-5-NITRO-QUINOLINE
• Synonyms: 4-CHLORO-2-METHYL-5-NITRO-QUINOLINE
• CAS NO: 145363-63-9
• Molecular Formula: C10H7ClN2O2
• Molecular Weight: 222.63
• Mol File: 145363-63-9.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-CHLORO-2-METHYL-5-NITRO-QUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-2-METHYL-5-NITRO-QUINOLINE(145363-63-9)
• EPA Substance Registry System: 4-CHLORO-2-METHYL-5-NITRO-QUINOLINE(145363-63-9)

Safety Data

• Hazardous Substances Data: 145363-63-9(Hazardous Substances Data)

Upstream product

• 4295-06-1 4-chloro-2-methylquinoline 

Relevant articles and documents

Synthesis and antitumor properties of bis (quinaldine) derivatives

A series of 7-nitro. and amino-N,N'-bis(4-quinaldinyl)-αω-diaminoalkanes related to the 6-amino derivative was synthezied and tested in the mouse P-388 lymphocytic leukemia screen. Three of the 7-nitro derivatives were found to have moderate activity (T/C 140-150%), while other nitro derivatives were devoid of any antitumor properties. All five 7-amino compounds were moderately to strongly active (T/C 134-196%). In addition, binding of amino derivatives 2-6 to DNA was examined by their ability to (1) stabilize DNA to thermal denaturation and (2) inhibit the DNA-dependent RNA polymerase reaction in vitro. T(m) data suggest that these compounds bind to DNA and are strong inhibitors of the polymerase reaction (I50 = 6-9 X 10-6 M).