145451-91-8

Basic information

• Product Name: METHYL (2R,3S)-2-BENZYLAMINO-3-HYDROXY-2-HYDROXYMETHYL-4-METHYLPENTANOATE
• Synonyms: METHYL (2R,3S)-2-BENZYLAMINO-3-HYDROXY-2-HYDROXYMETHYL-4-METHYLPENTANOATE;(3S)-3-Hydroxy-2-(hydroxyMethyl)-N-(phenylMethyl)-D-leucine Methyl Ester;YVDOZNHDZMCBLR-DZGCQCFKSA-N
• CAS NO: 145451-91-8
• Molecular Formula: C₁₅H₂₃NO₄
• Molecular Weight: 281.35
• Product Categories: Chiral Reagents;Intermediates
• Mol File: 145451-91-8.mol
• Article Data: 2

Chemical Properties

• Melting Point: 66-67°C
• Appearance: /
• Solubility: Acetone, Dichloromethane, Ethyl Acetate, Methanol
• CAS DataBase Reference: METHYL (2R,3S)-2-BENZYLAMINO-3-HYDROXY-2-HYDROXYMETHYL-4-METHYLPENTANOATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL (2R,3S)-2-BENZYLAMINO-3-HYDROXY-2-HYDROXYMETHYL-4-METHYLPENTANOATE(145451-91-8)
• EPA Substance Registry System: METHYL (2R,3S)-2-BENZYLAMINO-3-HYDROXY-2-HYDROXYMETHYL-4-METHYLPENTANOATE(145451-91-8)

Safety Data

• Hazardous Substances Data: 145451-91-8(Hazardous Substances Data)

Usage

Description

METHYL (2R,3S)-2-BENZYLAMINO-3-HYDROXY-2-HYDROXYMETHYL-4-METHYLPENTANOATE, with the CAS number 145451-91-8, is a white powder compound that is primarily used in organic synthesis. Its unique chemical structure and properties make it a valuable component in the creation of various organic compounds.

Uses

Used in Organic Synthesis:
METHYL (2R,3S)-2-BENZYLAMINO-3-HYDROXY-2-HYDROXYMETHYL-4-METHYLPENTANOATE is used as a key intermediate in the synthesis of complex organic molecules. Its versatile structure allows for the formation of a wide range of compounds, making it a valuable asset in the field of organic chemistry.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, METHYL (2R,3S)-2-BENZYLAMINO-3-HYDROXY-2-HYDROXYMETHYL-4-METHYLPENTANOATE is used as a building block for the development of new drugs. Its unique chemical properties enable the creation of novel drug candidates with potential therapeutic applications.
Used in Chemical Research:
METHYL (2R,3S)-2-BENZYLAMINO-3-HYDROXY-2-HYDROXYMETHYL-4-METHYLPENTANOATE is also utilized in chemical research to study the properties and reactivity of various organic compounds. Its use in research helps to advance the understanding of organic chemistry and contribute to the development of new synthetic methods and techniques.

Upstream product

• 319494-30-9 2,2-Dimethyl-propionic acid (2S,3R,5S)-5-benzyl-3-cyano-2-isopropyl-6-oxo-morpholin-3-ylmethyl ester 
• 219691-06-2 (2R,3S)-2-Amino-3-hydroxy-2-hydroxymethyl-4-methyl-pentanoic acid 
• 100-52-7 benzaldehyde 
• 145451-90-7 (2R,4R)-3-Benzyl-2-tert-butyl-4-((S)-1-hydroxy-2-methyl-propyl)-oxazolidine-4-carboxylic acid methyl ester 

Downstream Products

• 145452-03-5 (1S,6R,7S,7aS)-7-Hydroxy-1-isopropyl-6-methyl-5-oxo-dihydro-pyrrolo[1,2-c]oxazole-7a-carbaldehyde 
• 145452-02-4 (1S,6R,7S,7aS)-7-Hydroxy-7a-hydroxymethyl-1-isopropyl-6-methyl-tetrahydro-pyrrolo[1,2-c]oxazol-5-one 
• 145451-97-4 (3R,4S,5R,1'S)-4-hydroxy-5-(1'-hydroxy-2'-methylpropyl)-3-methylpyrrolidin-2-one-5-carboxylic acid 
• 145451-96-3 (1S,6R,7S,7aS)-7-Hydroxy-1-isopropyl-6-methyl-5-oxo-dihydro-pyrrolo[1,2-c]oxazole-7a-carboxylic acid 
• 145451-95-2 (1S,6R,7S,7aS)-7a-(tert-Butyl-dimethyl-silanyloxymethyl)-7-hydroxy-1-isopropyl-6-methyl-tetrahydro-pyrrolo[1,2-c]oxazol-5-one 
• 145452-01-3 [(4R,5S)-3-Benzyl-4-(tert-butyl-dimethyl-silanyloxymethyl)-5-isopropyl-oxazolidin-4-yl]-methanol 
• 145484-22-6 (4R,5S)-3-Benzyl-4-(tert-butyl-dimethyl-silanyloxymethyl)-5-isopropyl-oxazolidine-4-carbaldehyde 
• 145451-93-0 (4R,5S)-3-Benzyl-4-(tert-butyl-dimethyl-silanyloxymethyl)-5-isopropyl-oxazolidine-4-carboxylic acid methyl ester 
• 133343-34-7 Lactacystin 
• 145552-70-1 (2S,3R)-3-[(4S,5S)-3-Benzyl-4-(tert-butyl-dimethyl-silanyloxymethyl)-5-isopropyl-oxazolidin-4-yl]-3-hydroxy-2-methyl-propionic acid 2,6-dimethyl-phenyl ester 

Relevant articles and documents

Asymmetric Strecker route toward the synthesis of the Corey intermediate of lactacystin

An efficient synthesis of Corey's precursor (2) of lactacystin has been accomplished by the use of asymmetric Strecker synthesis of α-acyloxyketone 4 having L-Phe as a chirality transferring group.