145464-28-4

Basic information

• Product Name: Capromab Pendetide
• Synonyms: Capromab Pendetide;Cytogen 356;Immunoglobulin G 1 (mouse monoclonal 7E11-C5.3 anti-human prostatic carcinoma cell), disulfide with mouse monoclonal 7E11-C5.3 light chain, dimer, N(sup 6)-(N-(2-((2-(bis(carboxymethyl)amino)ethyl)(carboxymethyl)amino)ethyl)-N-(carboxymethyl)glycyl)-N(sup 2)-(N-glycyl-L-tyrosyl)-L-lysine conjugate;Oncoscint prostate;Prostascint
• CAS NO: 145464-28-4
• Molecular Formula: C10H15N5O11P2
• Molecular Weight: 443.200522
• Mol File: 145464-28-4.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Capromab Pendetide(CAS DataBase Reference)
• NIST Chemistry Reference: Capromab Pendetide(145464-28-4)
• EPA Substance Registry System: Capromab Pendetide(145464-28-4)

Safety Data

• Hazardous Substances Data: 145464-28-4(Hazardous Substances Data)

Usage

Description

Capromab Pendetide, also known as ProstaScint Kit, is a monoclonal antibody (MAb) derived from an initial sensitization with a glycoprotein expressed by prostate epithelium known as prostate surface membrane antigen (PSMA). It is a murine IgG1 κ that specifically recognizes PSMA, making it a highly specific diagnostic tool for prostate adenocarcinomas. The drug is used in conjunction with indium-111, which is joined to the antibody through a linker-chelator, glycyltyrosyl-(N-ethylenetriaminepentaacetic acid)-lysine HCl.

Uses

Used in Diagnostic Imaging:
Capromab Pendetide is used as a diagnostic imaging agent for newly diagnosed patients with proven prostate cancer who are at high risk for pelvic lymph metastasis. It helps in identifying primary and metastatic prostate cancer lesions, as the cytoplasmic domain marker 7E11-C5.3 reacts with more than 95% of adenocarcinomas evaluated.
Used in Prostate Cancer Detection:
Capromab Pendetide is used as a detection agent for prostate cancer, specifically adenocarcinomas. Its high specificity for PSMA allows for accurate identification of cancerous cells, aiding in the diagnosis and treatment planning for patients with prostate cancer.
Used in Medical Research:
Capromab Pendetide is used as a research tool for studying the biology and behavior of prostate cancer cells. Its specificity for PSMA makes it a valuable asset in understanding the mechanisms underlying prostate cancer development and progression, potentially leading to the discovery of new therapeutic targets and treatment strategies.