1454704-56-3Relevant articles and documents
Pyrroloindolone synthesis via a Cp*CoIII-catalyzed redox-neutral directed C-H alkenylation/annulation sequence
Ikemoto, Hideya,Yoshino, Tatsuhiko,Sakata, Ken,Matsunaga, Shigeki,Kanai, Motomu
supporting information, p. 5424 - 5431 (2014/05/06)
A unique synthetic utility of a Cp*CoIII catalyst in comparison with related Cp*RhIII catalysts is described. A C2-selective indole alkenylation/annulation sequence proceeded smoothly with catalytic amount of a [Cp*CoIII(C6H 6)](PF6)2 complex and KOAc. Intramolecular addition of an alkenyl-Cp*Co species to a carbamoyl moiety gave pyrroloindolones in 58-89% yield in one pot. Clear difference was observed between the catalytic activity of the Cp*CoIII complex and those of Cp*RhIII complexes, highlighting the unique nucleophilic activity of the organocobalt species. The Cp*CoIII catalysis was also suitable for simple alkenylation process of N-carbamoyl indoles, and broad range of alkynes, including terminal alkynes, were applicable to give C2-alkenylated indoles in 50-99% yield. Mechanistic studies on C-H activation step under Cp*CoIII catalysis with the aid of an acetate unit as well as evaluation of the difference between organo-Co III species and organo-RhIII species are also described.
Ruthenium-catalyzed regioselective C2 alkenylation of indoles and pyrroles via C-H bond functionalization
Li, Bin,Ma, Jianfeng,Xie, Weijia,Song, Haibin,Xu, Shansheng,Wang, Baiquan
, p. 9345 - 9353 (2013/10/08)
An efficient ruthenium-catalyzed oxidative coupling of indoles and pyrroles with various alkenes at the C2-position assisted by employing the N,N-dimethylcarbamoyl moiety as a directing group is reported. The catalytic reaction proceeds in an excellent regio- and stereoselective manner.