1454775-05-3Relevant articles and documents
Evaluation of the Influence of thiosemicarbazone-triazole hybrids on genes implicated in lipid oxidation and accumulation as potential anti-obesity agents
Kinfe, Henok H.,Belay, Yonas H.,Joseph, Jitcy S.,Mukwevho, Emmanuel
, p. 5275 - 5278 (2013)
A series of thiosemicarbazone-triazole hybrids 1a-h are efficiently synthesised and evaluated for their influence on the expression of genes, cpt-1, acc-1 and pgc-1, which are essential in lipid metabolism. The test results show that hybrids 1c and 1g exhibited relatively high influence on the expression of cpt-1 and pgc-1 and suppression of acc-1 as desired.