145641-35-6 Usage
Description
Benzyl (2S,3aR,7aS)-octahydroindole-2-carboxylate hydrochloride is a chemical compound with a complex structure, characterized by its specific stereochemistry. It is an ester derivative of octahydroindole-2-carboxylic acid, with a benzyl group attached to the carboxylate group. Benzyl (2S,3aR,7aS)-octahydroindole-2-carboxylate hydrochloride is typically found as an impurity in the synthesis of certain pharmaceuticals, such as Trandolapril, which is an antihypertensive and angiotensin-converting enzyme (ACE) inhibitor.
Uses
Used in Pharmaceutical Industry:
Benzyl (2S,3aR,7aS)-octahydroindole-2-carboxylate hydrochloride is used as an impurity in the synthesis of Trandolapril (T713500) for its role as an antihypertensive and ACE inhibitor. The presence of this compound in the synthesis process can affect the purity and efficacy of the final drug product, making it important to monitor and control its levels during manufacturing.
Used in Quality Control and Analysis:
In the pharmaceutical industry, Benzyl (2S,3aR,7aS)-octahydroindole-2-carboxylate hydrochloride is also used as a reference compound for quality control and analytical purposes. It helps in the identification, quantification, and assessment of the purity of Trandolapril and other related compounds, ensuring the safety and efficacy of the final drug product.
Used in Research and Development:
Benzyl (2S,3aR,7aS)-octahydroindole-2-carboxylate hydrochloride serves as a valuable research tool for scientists and researchers working on the development of new antihypertensive drugs and ACE inhibitors. It can be used to study the structure-activity relationships, pharmacological properties, and potential side effects of related compounds, contributing to the advancement of drug discovery and development in the cardiovascular field.
Check Digit Verification of cas no
The CAS Registry Mumber 145641-35-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,5,6,4 and 1 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 145641-35:
(8*1)+(7*4)+(6*5)+(5*6)+(4*4)+(3*1)+(2*3)+(1*5)=126
126 % 10 = 6
So 145641-35-6 is a valid CAS Registry Number.
InChI:InChI=1/C16H21NO2.ClH/c18-16(19-11-12-6-2-1-3-7-12)15-10-13-8-4-5-9-14(13)17-15;/h1-3,6-7,13-15,17H,4-5,8-11H2;1H/t13-,14+,15+;/m1./s1
145641-35-6Relevant articles and documents
PROCESSES FOR THE SYNTHESIS OF (2S, 3AR, 7AS)-OCTAHYDRO-1H-INDOLE CARBOXYLIC ACID AS AN INTERMEDIATE FOR TRANDOLAPRIL
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, (2011/02/24)
Processes for the preparation of (2S, 3aR, 7aS) -octahydro-1H-indole-20carboxylic acid hydrochloride starting from (1S, 2S) -2- [ (S) -1- phenylethyl amino] cyclohexyl) methanol are described.
Process for the synthesis of ?2S, 3aR, 7aS|-octahydroindole-2-carboxylic acid and its conversion to trandolapril
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Page/Page column 14, (2010/11/24)
The present invention describes a novel method for the synthesis of (2S,3aR,7aS)-octahydroindole-2-carboxylic acid of formula III using a new intermediate of formula II and conversion of the product of formula-III to trandolapril of formula I