145667-74-9

Basic information

• Product Name: (1S,5R,6R,7R)-6-<(3S)-3-hydroxy-5-phenyl-1-pentyl>-7-<(4-phenylbenzoyl)oxy>-2-oxabicyclo<3.3.0>octan-3-one
• Synonyms: (1S,5R,6R,7R)-6-<(3S)-3-hydroxy-5-phenyl-1-pentyl>-7-<(4-phenylbenzoyl)oxy>-2-oxabicyclo<3.3.0>octan-3-one
• CAS NO: 145667-74-9
• Molecular Weight: 484.592
• Mol File: 145667-74-9.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (1S,5R,6R,7R)-6-<(3S)-3-hydroxy-5-phenyl-1-pentyl>-7-<(4-phenylbenzoyl)oxy>-2-oxabicyclo<3.3.0>octan-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: (1S,5R,6R,7R)-6-<(3S)-3-hydroxy-5-phenyl-1-pentyl>-7-<(4-phenylbenzoyl)oxy>-2-oxabicyclo<3.3.0>octan-3-one(145667-74-9)
• EPA Substance Registry System: (1S,5R,6R,7R)-6-<(3S)-3-hydroxy-5-phenyl-1-pentyl>-7-<(4-phenylbenzoyl)oxy>-2-oxabicyclo<3.3.0>octan-3-one(145667-74-9)

Safety Data

• Hazardous Substances Data: 145667-74-9(Hazardous Substances Data)

Upstream product

• 41639-73-0 (1S,5R,6R,7R)-6-<(3R)-3-hydroxy-5-phenyl-1-pentenyl>-7-<(4-phenylbenzoyl)oxy>-2-oxabicyclo<3.3.0>octan-3-one 
• 169560-51-4 (1S,5R,6R,7R)-6-<(3S)-3-hydroxy-5-(2-iodophenyl)-1-(E)-pentenyl>-7-(4-phenylbenzoyloxy)-2-oxabicyclo<3.3.0>octane-3-one 
• 31752-99-5 (-)-Corey lactone 5-(4-phenylbenzoate) 
• 2344-70-9 (R)-4-phenyl-2-butanol 
• 38754-71-1 (3aR,4R,5R,6aS)-4-formyl-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl biphenyl-4-carboxylate 
• 41639-72-9 (1S,5R,6R,7R)-6-(3-oxo-5-phenyl-1E-pentenyl)-7-<(4-phenylbenzoyl)oxy>-2-oxabicyclo<3.3.0>octan-3-one 
• 100-39-0 benzyl bromide 

Downstream Products

• 145773-22-4 isopropyl (Z)-7-{(1R,2R,3R,5S)-3,5-dihydroxy-2-[(S)-3-hydroxy-5-phenylpentyl]cyclopentyl}hept-5-enoate 
• 41639-84-3 (15S)-13,14-dihydro-17-phenyl-18,19,20-trinor-PGF_2α 
• 352276-28-9 (1S,5R,6R,7R)-6-<(3S)-3-hydroxy-5-phenyl-1-pentyl>-7(R)-hydroxy-2-oxabicyclo<3.3.0>octan-3-ol 
• 145667-75-0 (1S,5R,6R,7R)-6-<(3S)-3-hydroxy-5-phenyl-1-pentyl>-7(R)-hydroxy-2-oxabicyclo<3.3.0>octan-3-one 

Relevant articles and documents

Preparation method of latanoprost

The invention provides a preparation method of latanoprost. Compared with methods in the prior art, the method has the advantages of few steps, high yield, high product purity, avoidance of a hydrogenation reduction process and a chiral reduction or chiral resolution process, great reduction of the cost, improvement of the safety, small discharge amount of three wastes, high environmental protection property, and especially suitable for industrial application to produce latanoprost.

Ligand-controlled palladium-catalyzed intramolecular reactions of phenyl-substituted prostaglandin P(2α) analogues

Palladium catalyzed intramolecular cyclization of the 15R and 15S epimers of 17-(2-iodophenyl)-18,19,20-trinorprostaglandin F(2α) isopropylester [(15R)-5 and (15S)-5, respectively] produce a complex mixture of products including various tetrahydronaphthol