145733-56-8

Basic information

• Product Name: 2-[5-(HYDROXYMETHYL)-2-PYRIDINYL]-BENZONITRILE
• Synonyms: 2-[5-(HYDROXYMETHYL)-2-PYRIDINYL]-BENZONITRILE;2-(5-(HydroxyMethyl)pyridin-2-yl)benzonitrile
• CAS NO: 145733-56-8
• Molecular Formula: C13H10N2O
• Molecular Weight: 210.235
• Mol File: 145733-56-8.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-[5-(HYDROXYMETHYL)-2-PYRIDINYL]-BENZONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[5-(HYDROXYMETHYL)-2-PYRIDINYL]-BENZONITRILE(145733-56-8)
• EPA Substance Registry System: 2-[5-(HYDROXYMETHYL)-2-PYRIDINYL]-BENZONITRILE(145733-56-8)

Safety Data

• Hazardous Substances Data: 145733-56-8(Hazardous Substances Data)

Usage

General Description

2-[5-(hydroxymethyl)-2-pyridinyl]-benzonitrile is a chemical compound with a molecular formula of C13H10N2O. It is a derivative of benzonitrile and contains a pyridine ring with a hydroxymethyl group attached to it. 2-[5-(HYDROXYMETHYL)-2-PYRIDINYL]-BENZONITRILE has potential applications in medicinal chemistry and pharmaceutical research due to its structural features and potential biological activities. Additionally, the presence of the benzene and nitrile groups in its structure suggests that it may have potential uses in organic synthesis and material science. Further research and exploration of this chemical's properties and potential applications may reveal its role in various fields of science and industry.

Upstream product

• 145733-55-7 2-<5-<<(tert-butyldimethylsilyl)oxy>methyl>pyridin-2-yl>benzonitrile 
• 6311-35-9 6-bromonicotinic acid 
• 145733-53-5 2-bromo-5-(tert-butyldimethylsilyloxy methyl)-pyridine 
• 122306-01-8 2-bromo-5-(hydroxymethyl)pyridine 

Downstream Products

• 154352-39-3 2-[5-(aminomethyl)pyridin-2-yl]benzonitrile hydrobromide 
• 154352-37-1 4-Methyl-2-propyl-1-[[2-(2-cyanophenyl)-5-pyridinyl]methyl]-1H-benzimidazole 
• 145733-66-0 2-Methyl-4-trifluoromethyl-5,6,8-trihydro-8-[[6-(2-cyanophenyl)-3-pyridinyl]methyl]-7H-pyrido[2,3-d]pyrimidin-7-one 
• 145733-64-8 5,8-dihydro-2,4-dimethyl-8-<<6-(2-cyanophenyl)-3-pyridinyl>methyl>pyrido<2,3-d>pyrimidin-7(6H)-one 
• 145733-57-9 2-<5-(chloromethyl)pyridin-2-yl>benzonitrile 

Relevant articles and documents

Rhodium(iii)-catalyzed aromatic C-H cyanation with dimethylmalononitrile as a cyanating agent

A rhodium-catalyzed aromatic C-H bond direct cyanation with safe, bench-stable, and commercially available dimethylmalononitrile as the cyanating agent has been successfully developed by using copper oxide as a promotor. Pyridine, quinoline, pyrimidine and pyrazole were used as the directing group in this type of C-H bond direct cyanation reaction.

Pyridopyrimidine Angiotensin II Antagonists

A series of pyridopyrimidine angiotensin II (A II) antagonists was synthesized and tested for antagonism of A II. Compounds with a biphenyltetrazole pharmacophore and small alkyl groups at the 2- and 4-positions of the pyridopyrimidine ring were found to be the most potent in an AT1 receptor binding assay and in blocking the A II pressor response in anesthetized, ganglion-blocked A II-infused rats. 5,8-Dihydro-2,4-dimethyl-8--4-yl)methyl>pyridopyrimidin-7(6H)-one (4a) was one of the more potent compounds in the binding assay and was the most efficacious compound in the A II-infused rat model. Further study of 4a in Goldblatt (2K-1C) rats showed the compound to have oral bioavailability and to be an efficacious and potent compound in a high renin form of hypertension.

SUBSTITUTED PYRRIDOPYRIMIDINES USEFUL AS ANGIOTENSIN II ANTAGONISTS

This invention relates to pyrrolo-, pyrido-, azepino-, and azocinopyrimidines of the general formula I STR1 useful for treating hypertension and congestive heart failure, to pharmaceutical compositions, and to methods for production thereof.