145850-78-8

Basic information

• Product Name: 1-((2R,3R,4S,5S,6S)-6-Carboxy-3,4,5-trihydroxy-tetrahydro-pyran-2-yl)-1-methyl-4-[3-(2-trifluoromethyl-phenothiazin-10-yl)-propyl]-piperazin-1-ium; chloride
• CAS NO: 145850-78-8
• Molecular Weight: 620.09
• Mol File: 145850-78-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-((2R,3R,4S,5S,6S)-6-Carboxy-3,4,5-trihydroxy-tetrahydro-pyran-2-yl)-1-methyl-4-[3-(2-trifluoromethyl-phenothiazin-10-yl)-propyl]-piperazin-1-ium; chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 1-((2R,3R,4S,5S,6S)-6-Carboxy-3,4,5-trihydroxy-tetrahydro-pyran-2-yl)-1-methyl-4-[3-(2-trifluoromethyl-phenothiazin-10-yl)-propyl]-piperazin-1-ium; chloride(145850-78-8)
• EPA Substance Registry System: 1-((2R,3R,4S,5S,6S)-6-Carboxy-3,4,5-trihydroxy-tetrahydro-pyran-2-yl)-1-methyl-4-[3-(2-trifluoromethyl-phenothiazin-10-yl)-propyl]-piperazin-1-ium; chloride(145850-78-8)

Safety Data

• Hazardous Substances Data: 145850-78-8(Hazardous Substances Data)

Upstream product

• 117-89-5 Trifluoperazine 
• 21085-72-3 1-bromo-2,3,4-tri-O-acetyl-α-D-glucuronic acid methyl ester 

Relevant articles and documents

Synthesis and characterization of quaternary ammonium-linked glucuronide metabolites of drugs with an aliphatic tertiary amine group

A synthetic approach was developed to make the quaternary ammonium-linked glucuronide metabolites of compounds with an aliphatic tertiary amine group. The key step involved quaternization of the compound with methyl (2,3,4-tri- O-acetyl-α-D-glucopyranosyl bromide)uronate and sodium bicarbonate in a two- phase system of water and an organic solvent. The synthetic approach successfully yielded quaternary ammonium-linked glucuronides of 20 drugs and two of their phase I metabolites. The drugs were from various pharmacological classes: H1 antihistamines, antipsychotic agents, and tricyclic antidepressants. Physical data such as HPLC retention times, and diagnostic fast-atom bombardment mass spectra and 1H NMR spectra were obtained. These should aid in the characterization of compounds in samples isolated from biological media.