145901-58-2Relevant articles and documents
Rapid oligosaccharide synthesis on a fluorous support
Goto, Kohtaro,Miura, Tsuyoshi,Hosaka, Daisuke,Matsumoto, Hiroharu,Mizuno, Mamoru,Ishida, Hide-Ki,Inazu, Toshiyuki
, p. 8845 - 8854 (2004)
The novel fluorous support Hfb (hexakisfluorous chain-type butanoyl) was easily prepared. The Hfb group was readily introduced into the anomeric hydroxyl group of a carbohydrate, and was recyclable after cleavage. The use of the Hfb group was applicable for the rapid oligosaccharide synthesis in which the synthetic intermediates could be purified using fluorous and normal organic solvents. Each synthetic intermediate could be monitored by TLC, NMR and mass spectrometry. Graphical Abstract
Oligosaccharide synthesis on a fluorous support
Miura, Tsuyoshi,Goto, Kohtaro,Hosaka, Daisuke,Inazu, Toshiyuki
, p. 2047 - 2051 (2003)
The fluorous support Hfb (see picture) enabled high-yielding oligosaccharide syntheses in which the synthetic intermediates could be purified by simple fluorous-organic solvent extraction, and the reactions could be monitored spectroscopically and by TLC.