1459243-96-9

Basic information

• Product Name: (Z)-3-(2-phenylethylidene)isobenzofuran-1(3H)-one
• Synonyms: (Z)-3-(2-phenylethylidene)isobenzofuran-1(3H)-one
• CAS NO: 1459243-96-9
• Molecular Weight: 236.27
• Mol File: 1459243-96-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (Z)-3-(2-phenylethylidene)isobenzofuran-1(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-3-(2-phenylethylidene)isobenzofuran-1(3H)-one(1459243-96-9)
• EPA Substance Registry System: (Z)-3-(2-phenylethylidene)isobenzofuran-1(3H)-one(1459243-96-9)

Safety Data

• Hazardous Substances Data: 1459243-96-9(Hazardous Substances Data)

Upstream product

• 1459244-08-6 C₁₆H₁₃F₃O₄S 
• 12539-63-8 carbon monoxide 
• 726-26-1 phenyl 3-phenylpropanoate 
• 88-67-5 2-Iodobenzoic acid 
• 10147-11-2 propargyl benzene 
• 128174-46-9 (E)-3-styrylisobenzofuran-1(3H)-one 
• 13203-89-9 3-phenacylphthalide 
• 188716-83-8 3-(2-hydroxy-2-phenylethyl)isobenzofuran-1(3H)-one 
• 119-67-5 o-carboxybenzaldehyde 
• 98-86-2 acetophenone 

Relevant articles and documents

Practical synthesis of 3-(2-arylethylidene)isoindolin-1-ones (analogues of AKS-182) and 3-(2-arylethylidene)isobenzofuran-1(3H)-ones

A simple and practical method is reported for the synthesis of 3-(2-arylethylidene)isoindolin-1-ones and 3-(2-arylethylidene)isobenzofuran-1(3H)-ones, proceeding with good to excellent yields and (E:Z) selectivity. This methodology involves the sequential reduction-dehydration reaction of readily obtained 3-(2-oxo-2-arylethyl)isoindolin-1-ones and 3-(2-oxo-2-arylethyl)isobenzofuran-1(3H)-ones followed by a base-catalyzed double bond isomerization with K2CO3 in acetonitrile. The development of a concise synthesis of AKS-182 has been achieved using this methodology.

3-Ylidenephthalides as a new class of transient receptor potential channel TRPA1 and TRPM8 modulators

Following the recent identification of the naturally occurring 3-ylidene-4,5-dihydrophthalide ligustilide and its oxidation product dehydroligustilide as novel TRPA1 modulators, a series of seventeen 3-ylidenephthalides was synthesized and tested on TRPA1 and TRPM8 channels. Most of these compounds acted as strong modulators of the two channel types with EC50 and/or IC50 values distinctly lower than those of the reference compounds.