145986-43-2 Usage
Description
[(2R,5R)-5-(2-amino-6-chloro-9H-purin-9-yl)-1,3-oxathiolan-2-yl]methanol is a complex chemical compound characterized by the presence of a purine ring, an oxathiolane ring, and a methanol group. It also features an amino group and a chlorine atom, which contribute to its potential biological activity. [(2R,5R)-5-(2-amino-6-chloro-9H-purin-9-yl)-1,3-oxathiolan-2-yl]methanol may interact with biological molecules such as proteins and nucleic acids, making it a promising candidate for applications in medicinal chemistry and biochemistry research.
Uses
Used in Medicinal Chemistry:
[(2R,5R)-5-(2-amino-6-chloro-9H-purin-9-yl)-1,3-oxathiolan-2-yl]methanol is used as a potential therapeutic agent for various medical conditions due to its complex structure and ability to interact with biological molecules. Its specific application reason is its potential to modulate cellular processes and target disease-related pathways.
Used in Biochemistry Research:
In the field of biochemistry, [(2R,5R)-5-(2-amino-6-chloro-9H-purin-9-yl)-1,3-oxathiolan-2-yl]methanol serves as a valuable research tool for studying the interactions between small molecules and biological macromolecules, such as proteins and nucleic acids. Its application reason is to facilitate a better understanding of molecular recognition and the development of new drugs or therapies.
Used in Pharmaceutical Industry:
Within the pharmaceutical industry, [(2R,5R)-5-(2-amino-6-chloro-9H-purin-9-yl)-1,3-oxathiolan-2-yl]methanol is used as a key intermediate in the synthesis of novel drugs. Its application reason is its unique structural features that can be exploited to design and develop new therapeutic agents with improved efficacy and selectivity.
Used in Drug Delivery Systems:
Similar to other bioactive compounds, [(2R,5R)-5-(2-amino-6-chloro-9H-purin-9-yl)-1,3-oxathiolan-2-yl]methanol can be incorporated into drug delivery systems to enhance its bioavailability, targeting, and overall therapeutic efficacy. Its application reason is to improve the pharmacokinetic properties and reduce potential side effects associated with direct administration of the compound.
Check Digit Verification of cas no
The CAS Registry Mumber 145986-43-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,5,9,8 and 6 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 145986-43:
(8*1)+(7*4)+(6*5)+(5*9)+(4*8)+(3*6)+(2*4)+(1*3)=172
172 % 10 = 2
So 145986-43-2 is a valid CAS Registry Number.
145986-43-2Relevant articles and documents
Asymmetric Synthesis and Biological Evaluation of β-L-(2R,5S)- and α-L-(2R,5R)-1,3-Oxathiolane-Pyrimidine and -Purine Nucleosides as Potential Anti-HIV Agents
Jeong, Lak S.,Shinazi, Raymond F.,Beach, J. Warren,Kim, Hea O.,Nampalli, Satyanarayana,et al.
, p. 181 - 195 (2007/10/02)
In order to study the structure-acivity relationships of L-oxathiolanyl nucleosides as potential anti-HIV agents, a series of enantiomerically pure L-oxathiolanyl pyrimidine and purine nucleosides were synthesized and evaluated for anti-HIV-1 activity in human peripheral blood mononuclear (PBM) cells.The key intermediate 8 was synthesized starting from L-gulose via 1,6-thiaanhydro-L-gulopyranose.The acetate 8 was condensed with thymine, 5-substituted uracils and cytosines, 6-chloropurine, and 6-chloro-2-fluoropurine to give pyrimidine and purine nucleosides.Upon evaluation of these final nucleosides, the 5-fluorocytosine derivative 51 was found to be the most potent compound among those tested.In the case of 5-substituted cytosine analogues, the antiviral potency was found to be in the following decreasing order: cytosine (β-isomer) > 5-iodocytosine (β-isomer) > 5-fluorocytosine (α-isomer) > 5-methylcytosine (α-isomer) > 5-methylcytosine (β-isomer) > 5-bromocytosine (β-isomer) > 5-chlorocytosine (β-isomer).Among the thymine, uracil, and 5-substituted uracil derivatives, thymine (α-isomer) and uracil (β-isomer) derivatives exhibited moderate anti-HIV activity.In the purine series, the antiviral potency is found to be in the following decreasing order: adenine (β-isomer) > 6-chloropurine (β-isomer) > 6-chloropurine (α-isomer) > 2-NH2-6-Cl-purine (β-isomer) > guanine (β-isomer) > N6-methyladenine (α-isomer) > N6-methyladenine (β-isomer).The cytotoxicity was also determined in human PBM cells as well as Vero cells.None of the synthesized nucleosides was toxic up to 100 μ in PBM cells.
