146143-29-5Relevant articles and documents
Total synthesis of optically active monocrotaline, a carcinogenic pyrrolizidine alkaloid possessing an eleven-membered retronecine dilactone
Niwa, Haruki,Ogawa, Takeshi,Okamoto, Osamu,Yamada, Kiyoyuki
, p. 10531 - 10548 (2007/10/02)
A total synthesis of the natural enantiomer of monocrotaline (1), a representative of carcinogenic pyrrolizidine alkaloids having an 11-membered retronecine dilactone was achieved through regioselective coupling of (+)-retronecine (3) and the optically active protected necic acid 8, the latter being prepared enantioselectively from the meso-diester 11.
