146198-05-2

Basic information

• Product Name: 5-(3,4-dimethoxyphenyl)-2,4-dihydro-[1,2,4]triazol-3-thione
• Synonyms: 5-(3,4-dimethoxyphenyl)-2,4-dihydro-[1,2,4]triazol-3-thione
• CAS NO: 146198-05-2
• Molecular Weight: 237.282
• Mol File: 146198-05-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5-(3,4-dimethoxyphenyl)-2,4-dihydro-[1,2,4]triazol-3-thione(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(3,4-dimethoxyphenyl)-2,4-dihydro-[1,2,4]triazol-3-thione(146198-05-2)
• EPA Substance Registry System: 5-(3,4-dimethoxyphenyl)-2,4-dihydro-[1,2,4]triazol-3-thione(146198-05-2)

Safety Data

• Hazardous Substances Data: 146198-05-2(Hazardous Substances Data)

Upstream product

• 2150-38-1 methyl 3,4-dimethoxybenzoate 
• 41764-74-3 3,4-dimethoxybenzohydrazide 
• 93-07-2 Veratric acid 

Downstream Products

• 146198-10-9 2-(3,4-Dimethoxy-phenyl)-6,7-dihydro-5H-[1,2,4]triazolo[5,1-b][1,3]thiazin-6-ol 
• 146198-18-7 Acetic acid 2-(3,4-dimethoxy-phenyl)-6,7-dihydro-5H-[1,2,4]triazolo[5,1-b][1,3]thiazin-6-yl ester 
• 146198-28-9 6-Chloro-2-(3,4-dimethoxy-phenyl)-6,7-dihydro-5H-[1,2,4]triazolo[5,1-b][1,3]thiazine 

Relevant articles and documents

Synthesis of new S-alkylated-3-mercapto-1,2,4-triazole derivatives bearing cyclic amine moiety as potent anticancer agents

A series of 3-[3-[4-(Substituted)-1-cyclicamine]propyl]thio-5- substituted[1,2,4]triazoles (8a-j) were synthesized with good yields starting from corresponding carboxylic acids. The cytotoxicity studies of these derivatives were studied against five different human cancer cell lines. Three compounds had shown good anticancer activity. The triazole derivatives, 8i and 8j were most potent particularly against U937 and HL-60 cells. The cytotoxic potency of the compounds varied between the cell lines suggesting that a structural property of these compounds as possible determinants of their biological activity.

Cytoprotection utilizing aryltriazol-3-thiones

5-Aryltriazol-3-thiones are useful for inhibiting adhesion of Mac-1 and thereby providing cytoprotection for diseases mediated by Mac-1 adhesion.