1462237-48-4Relevant articles and documents
Synthesis and in vitro evaluation of a multifunctional and surface-switchable nanoemulsion platform
Gianella, Anita,Mieszawska, Aneta J.,Hoeben, Freek J. M.,Janssen, Henk M.,Jarzyna, Peter A.,Cormode, David P.,Costa, Kevin D.,Rao, Satish,Farokhzad, Omid C.,Langer, Robert,Fayad, Zahi A.,Mulder, Willem J. M.
, p. 9392 - 9394 (2013)
We present a multifunctional nanoparticle platform that has targeting moieties shielded by a matrix metalloproteinase-2 (MMP2) cleavable PEG coating. Upon incubation with MMP2 this surface-switchable coating is removed and the targeting ligands become available for binding. The concept was evaluated in vitro using biotin and αvβ3-integrin-specific RGD-peptide functionalized nanoparticles.