146329-57-9

Basic information

• Product Name: tetramethylammonium 5,7-dihydroxy-4-oxo-2-phenyl-4H-chromen-8-yl sulfate
• Synonyms: tetramethylammonium 5,7-dihydroxy-4-oxo-2-phenyl-4H-chromen-8-yl sulfate
• CAS NO: 146329-57-9
• Molecular Weight: 423.444
• Mol File: 146329-57-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: tetramethylammonium 5,7-dihydroxy-4-oxo-2-phenyl-4H-chromen-8-yl sulfate(CAS DataBase Reference)
• NIST Chemistry Reference: tetramethylammonium 5,7-dihydroxy-4-oxo-2-phenyl-4H-chromen-8-yl sulfate(146329-57-9)
• EPA Substance Registry System: tetramethylammonium 5,7-dihydroxy-4-oxo-2-phenyl-4H-chromen-8-yl sulfate(146329-57-9)

Safety Data

• Hazardous Substances Data: 146329-57-9(Hazardous Substances Data)

Upstream product

• 480-40-0 5,7-dihydroxy-2-phenyl-chromen-4-one 
• 75-59-2 tetramethyl ammoniumhydroxide 

Relevant articles and documents

Discovery and synthesis of novel Wogonin derivatives with potent antitumor activity in vitro

Phenotypic screening of high quality compound library is one of the most effective strategy to obtain novel bioactive compounds. Recently, our group have constructed a Wogonin-scaffold library with substituents diversity and successfully obtained a series

Synthesis, evaluation and quantitative structure–activity relationship (QSAR) analysis of Wogonin derivatives as cytotoxic agents

A novel series of 49 wogonin derivatives were synthesized by introducing group at 7-, 8- or B ring of wogonin. The cytotoxic activities against HepG2, A549 and BCG-823 cancer cell lines were also investigated in vitro. Several of them showed obvious cytotoxic activities and compound 3h possessed the highest potency against HepG2, A549, and BCG-823 with IC50 values of 1.07 μM, 1.74 μM and 0.98 μM, respectively. A quantitative structure-activity relationship (QSAR) study of these synthetic derivatives as well as wogonin indicated that high solubility and low octanol/water partition coefficient are favorable, and excessive electrostatic properties and refractivity are unfavorable for the cytotoxic activities of these wogonin derivatives. These findings and results provide a base for further investigations.

Synthesis of 6-C-(3,3-Dimethyl-2-propen-1-yl)norwogonin

6-C-(3,3-Dimethyl-2-propen-1-yl)norwogonin was synthesized in 34percent yield by direct C-prenylation of 5,7-dihydroxy-8-sulfoxyflavone using 4-bromo-2-methyl-2-butene in aqueous tetramethylammonium hydroxide.Among the minor products of the reaction, 6-C-