1463459-30-4

Basic information

• Product Name: 14-O-[(2-chlorobenzamide-1,3,4-thiadiazole-5-yl)thioacetyl]mutilin
• Synonyms: 14-O-[(2-chlorobenzamide-1,3,4-thiadiazole-5-yl)thioacetyl]mutilin
• CAS NO: 1463459-30-4
• Molecular Weight: 632.245
• Mol File: 1463459-30-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 14-O-[(2-chlorobenzamide-1,3,4-thiadiazole-5-yl)thioacetyl]mutilin(CAS DataBase Reference)
• NIST Chemistry Reference: 14-O-[(2-chlorobenzamide-1,3,4-thiadiazole-5-yl)thioacetyl]mutilin(1463459-30-4)
• EPA Substance Registry System: 14-O-[(2-chlorobenzamide-1,3,4-thiadiazole-5-yl)thioacetyl]mutilin(1463459-30-4)

Safety Data

• Hazardous Substances Data: 1463459-30-4(Hazardous Substances Data)

Upstream product

• 31716-01-5 pleuromutilin tosylate 
• 76530-77-3 14-O-{[(5-amino-1,3,4-thiadiazol-2-yl)sulfanyl]acetyl}mutilin 
• 118-91-2 ortho-chlorobenzoic acid 
• 31716-03-7 (3aR,4R,5R,7S,8S,9R,9aS,12R)-8-hydroxy-4,7,9,12-tetramethyl-3-oxo-7-vinyldecahydro-4,9a-propanocyclopenta[8]annulen-5-yl 2-iodoacetate 

Relevant articles and documents

Pleuromutilin compounds with thioether side chains as well as preparation method and application of pleuromutilin compounds

The invention discloses pleuromutilin compounds with thioether side chains as well as a preparation method and an application of the pleuromutilin compounds and belongs to the field of medicinal chemistry. The compounds have the structure shown in the for

Synthesis and biological activities of novel pleuromutilin derivatives with a substituted thiadiazole moiety as potent drug-resistant bacteria inhibitors

A series of novel pleuromutilin derivatives possessing thiadiazole moieties were synthesized via acylation reactions under mild conditions. The in vitro antibacterial activities of the derivatives against methicillin-resistant Staphylococcus aureus, methicillin-resistant Staphylococcus epidermidis, Escherichia coli, and Streptococcus agalactiae were tested by the agar dilution method and Oxford cup assay. The majority of the tested compounds displayed moderate antibacterial activities. Importantly, the three compounds with amino or tertiary amine groups in their side chains, 11, 13b, and 15c, were the most active antibacterial agents. Docking experiments carried out on the peptidyl transferase center (PTC) of 23S rRNA proved that there is a reasonable direct correlation between the binding free energy (ΔGb, kcal/mol) and the antibacterial activity. Moreover, the pharmacokinetic profiles of 11 and 15c in rat were characterized by moderate clearance and oral bioavailability.