146346-82-9Relevant articles and documents
Synthesis of autophagosomal marker protein LC3-II under detergent-free conditions
Huang, Yi-Chao,Li, Yi-Ming,Chen, Yang,Pan, Man,Li, Yi-Tong,Yu, Li,Guo, Qing-Xiang,Liu, Lei
, p. 4858 - 4862 (2013)
Just add oil: A new detergent-free method was developed to synthesize lipidated proteins using a light-activatable solubilizing side chain (in dashed circle, see scheme) to assist the ligation of the lipopeptides. This method allows the efficient preparation of a phosphatidylethanolamine-conjugated autophagosomal marker protein (LC3-II) as well as labeled derivatives of LC3-II, which can be used to study autophagy regulation. Copyright
Synthesis of N-protected N-methyl serine and threonine
Luo, Yue,Evindar, Ghotas,Fishlock, Dan,Lajoie, Gilles A
, p. 3807 - 3809 (2007/10/03)
Two efficient and convenient syntheses of N-Cbz and N-Fmoc N-methyl serine and threonine are described. The amino acid side-chain alcohol can be protected as a TBDMS ether in very good yield or left free, followed by the formation and subsequent reduction of the corresponding oxazolidinone.
Application of t-Butyldimethylsilyl Ethers of Serine, Threonine and Tyrosine in Peptide Synthesis
Fischer, Peter M.
, p. 7605 - 7608 (2007/10/02)
The utility of Tbdms (t-butyldimethylsilyl) ethers, prepared conveniently in a one pot procedure from Nα-Fmoc (9-fluorenylmethoxycarbonyl) and Nα-Z (benzyloxycarbonyl) hydroxyamino acids, is demonstrated: peptide bond formation and esterification to 4-alkoxybenzylalcohol resin are achieved readily with these derivatives.The lability of the Tbdms ethers to various reagents enables selective deprotection of the hydroxyl side-chains assembly, desirable, e.g., for phosphorylation of glycosylation.