1463496-26-5

Basic information

• Product Name: 11-(4-chlorophenyl)-8,8-dimethyl-7,8,9,11-tetrahydro-1H-pyrazolo[3,4-a]acridin-10(6H)-one
• Synonyms: 11-(4-chlorophenyl)-8,8-dimethyl-7,8,9,11-tetrahydro-1H-pyrazolo[3,4-a]acridin-10(6H)-one
• CAS NO: 1463496-26-5
• Molecular Weight: 377.873
• Mol File: 1463496-26-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 11-(4-chlorophenyl)-8,8-dimethyl-7,8,9,11-tetrahydro-1H-pyrazolo[3,4-a]acridin-10(6H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 11-(4-chlorophenyl)-8,8-dimethyl-7,8,9,11-tetrahydro-1H-pyrazolo[3,4-a]acridin-10(6H)-one(1463496-26-5)
• EPA Substance Registry System: 11-(4-chlorophenyl)-8,8-dimethyl-7,8,9,11-tetrahydro-1H-pyrazolo[3,4-a]acridin-10(6H)-one(1463496-26-5)

Safety Data

• Hazardous Substances Data: 1463496-26-5(Hazardous Substances Data)

Upstream product

• 104-88-1 4-chlorobenzaldehyde 
• 126-81-8 dimedone 
• 7597-18-4 6-nitroindazole 
• 6967-12-0 6-amino-1H-indazole 

Relevant articles and documents

An Efficient Fe/H 2 O Medium in situ Reduction and Cyclization Reaction for the Synthesis of Pyrazolo[3,4- a ]acridin-10-one and Pyrazolo[4,3- a ]acridin-10-one Derivatives

An efficient and simple method for the synthesis of pyrazolo[3,4- a ]acridine and pyrazolo[4,3- a ]acridine derivatives directly form nitro compounds by in situ reduction and cyclization reaction under Fe/H 2 O medium is reported. Compared to amino compounds, nitro compounds are more stable and easier to obtain. In addition, because iron is a nontoxic, inexpensive, and environmentally friendly reductant, this method is especially suitable for organic synthesis. The other advantages of this process are cheap raw materials, less pollution, and wide substrate range.

Combinatorial synthesis of pyrazoloquinoline and pyrazoloacridine derivatives with high regioselectivity

Three-component reaction of aldehyde, 1H-indazol-6-amine and 1,3-dicarbonyl compounds in EtOH under catalyst-free conditions, generates the corresponding pyrazolo[3,4-a]acridine, cyclopenta[b]pyrazolo[3,4-f]quinoline, indeno[1,2-b]pyrazolo[3,4-f]quinoline and benzo[h]pyrazolo[3,4-a]acridine derivatives in high yields and regioselectivity, respectively. The dicarbonyl compounds include 5,5-dimethylcyclohexane-1,3-dione, cyclopentane-1,3-dione, 2H-indene-1,3-dione and 2-hydroxynaphthalene-1,4-dione.