14639-25-9 Usage
Description
Chromium picolinate is a complex of trivalent chromium and picolinic acid, which appears as a dark violet crystal with good fluidity. It is chemically stable at room temperature, slightly soluble in water, and insoluble in ethanol. The chromium is in the trivalent form, and the whole molecule structure is electrically neutral with hydrophobic properties. This allows for trans-membrane absorption on the intact structure, which is similar to the GTF (glucose tolerance factor) part. Chromium picolinate is known for its excellent absorption rate and ability to effectively play its biological function.
Uses
Used in Dietary Supplements:
Chromium picolinate is used as a dietary supplement for enhancing absorption of chromium, which is essential for maintaining healthy blood sugar and cholesterol levels. It is widely included in multivitamin and multimineral products, available in capsule or tablet form, with typical amounts ranging from 50 to 400 μg/day.
Used in Type 2 Diabetes Management:
Chromium picolinate is used as a supplement or alternative medicine for type 2 diabetes, as it has been shown to boost glucose uptake by activating P38 MAPK and enhance the action of insulin, thereby increasing insulin sensitivity in type 2 diabetes patients.
Used in Blood Cholesterol and Glucose Control:
Chromium picolinate is used to help control blood cholesterol and blood glucose levels, promoting the loss of fat and an increase in lean muscle tissue.
Used in Longevity and Osteoporosis Prevention:
Studies show that chromium picolinate may increase longevity and help fight osteoporosis.
Used in Insulin Resistance Research:
Chromium picolinate is used to study its potential as a modulator of glucose uptake and the activity of insulin, as well as its effects on nuclear factor-κB (NF-κB) and nuclear factor-E2-related factor-2 (Nrf2) pathways in animals.
Used in Anti-Diabetic Mechanisms:
Chromium picolinate is used in the study of its anti-diabetic mechanisms in insulin-resistant 3T3-L1 adipocytes.
Benefits
chromium Picolinate is a nutritional supplement that is needed in the body but in small amounts. It gives the body the muscle mass that it needs. It also ebbs out the bad fat as it increases muscle mass.Chromium Picolinate, like all herbs and minerals, it would be taken with the needed herbs to ensure proper function and good health in the body. Chromium Picolinate maintains the bodybuilding effect and nourishes the blood system.Chromium Picolinate helps maintain the good condition of a body that is gaining muscle, it helps maintain the blood pressure and blood sugar.After a hard day,Chromium Picolinate relaxes the muscle as it gains strength. stress is a daily occurrence in life,working out is work and may even tear muscles. Taking the Chromium Picolinate gives more of an assurance to the body muscles than not taking it at all.The Chromium Picolinate removes metals and toxins from the body system. It also removes mercury that may have been digested while eating, if there is a mercury filled metal inside the teeth.Gaining muscles also means having the need for energy.Moving about daily is so stressful it can cause the blood sugar to rise. It can cause blood pressure too. The Chromium Picolinate regulates the blood pressure, blood sugar and maintains the insulin in the body system to avoid any type of diabetes.
Side effects
Chromium picolinate has been associated with adverse effects. Unlike other forms of chromium,chromium picolinate moves from the bloodstream into cells intact, and then dissociates, and toxicity may be related to accumulation of intracellular chromium III ions or accumulation of picolinic acid. It has been associated with enhanced production of hydroxyl radicals,depletion of antioxidant enzymes,DNA damage and mutagenesis.Comparative cell studies of chromium picolinate and niacin-bound chromium have shown that chromium picolinate produces a greater amountof oxidative stress and DNA damage, and the picolinic acid component is believed to be largely responsible.In animals, it has been found to cause oxidative damage to lipids and DNA.However, in a short-term study, animals given 33,250 or 2000 mg/kg of chromium picolinate,equivalent to 4.1,30.8 and 246 mg/kg of chromium,showed no evidence of chromosomal damage in their bone marrow cells. Chromium picolinate has been implicated in a variety of adverse effects，including kidney and liver dysfunction, skin blisters and pustules,anaemia, haemolysis, tissue oedema and nerve damage.Many of the proposed adverse effects in humans are based on case reports in which chromium picolinate has not been proven to be the causative factor.In 2004,the UK Committee on Mutagenicity of Chemicals in Food，Consumer Products and the Environment reviewed the evidence, and concluded that the balance of the evidence suggested that chromium picolinate was not genotoxic, and that its use should not be restricted.
Biochem/physiol Actions
Chromium picolinate (CrPic) is a supplemental or alternative medication for type 2 diabetes. Experimental evidence shows the effect of CrPic on glucose uptake through the activation of p38 MAPK. Chromium is thought to potentiate the action of insulin, leading to increased insulin sensitivity in type 2 diabetes.
Check Digit Verification of cas no
The CAS Registry Mumber 14639-25-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,4,6,3 and 9 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 14639-25:
(7*1)+(6*4)+(5*6)+(4*3)+(3*9)+(2*2)+(1*5)=109
109 % 10 = 9
So 14639-25-9 is a valid CAS Registry Number.
InChI:InChI=1/3C6H5NO2.Cr/c3*8-6(9)5-3-1-2-4-7-5;/h3*1-4H,(H,8,9);/q;;;+3/p-3/rC18H12CrN3O6/c23-16(13-7-1-4-10-20-13)26-19(27-17(24)14-8-2-5-11-21-14)28-18(25)15-9-3-6-12-22-15/h1-12H
