146396-04-5

Basic information

• Product Name: N-(4-PHENYL-PIPERIDIN-4-YL)-ACETAMIDE
• Synonyms: N-(4-PHENYL-PIPERIDIN-4-YL)-ACETAMIDE;4-(Acetylamino)-4-phenylpiperidine;4-Acetamido-4-phenylpiperidine;N-(4-Phenyl-4-piperidinyl)acetamide
• CAS NO: 146396-04-5
• Molecular Formula: C₁₃H₁₈N₂O
• Molecular Weight: 218.29482
• Mol File: 146396-04-5.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 418.029°C at 760 mmHg
• Flash Point: 170.074°C
• Appearance: /
• Density: 1.09
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.561
• CAS DataBase Reference: N-(4-PHENYL-PIPERIDIN-4-YL)-ACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-PHENYL-PIPERIDIN-4-YL)-ACETAMIDE(146396-04-5)
• EPA Substance Registry System: N-(4-PHENYL-PIPERIDIN-4-YL)-ACETAMIDE(146396-04-5)

Safety Data

• Hazardous Substances Data: 146396-04-5(Hazardous Substances Data)

Usage

General Description

N-(4-phenylpiperidin-4-yl)-acetamide is a chemical compound with the molecular formula C15H20N2O. It is a piperidine derivative and an acetamide, and it is used in the field of medicinal chemistry for research purposes. N-(4-PHENYL-PIPERIDIN-4-YL)-ACETAMIDE has been studied for its potential biological activities, including its effects on the central nervous system and its potential as a drug target for various neurological conditions. Its specific pharmacological and toxicological properties are still under investigation, and it is not currently used in any commercial products.

InChI:InChI=1/C13H18N2O/c1-11(16)15-13(7-9-14-10-8-13)12-5-3-2-4-6-12/h2-6,14H,7-10H2,1H3,(H,15,16)

Upstream product

• 591-51-5 phenyllithium 
• 63843-83-4 1-benzyl-4-hydroxy-4-phenylpiperidine 
• 3612-20-2 1-phenylmethyl-4-piperidone 
• 172733-78-7 N-(1-benzyl-4-phenylpiperidin-4-yl)acetamide 

Downstream Products

• 1143582-72-2 C₂₅H₃₃N₃O 
• 181876-85-7 benzyl 5-(4-acetamido-4-phenylpiperidino)-3-(3,4-dichlorophenyl)pentanoate 
• 142001-63-6 SR 48212A 

Relevant articles and documents

1-(TRIAZIN-3-YL/PYRIDAZIN-3-YL)-PIPER(-AZINE)IDINE DERIVATIVES AND COMPOSITIONS THEREFOR FOR INHIBITING THE ACTIVITY OF SHP2

The present invention relates to compounds of formula I: in which Y1, Y2, Y3, R1, R2a, R2b, R3a, R3b, R4a, R4b, R5a, R5b are defined in the Summary of the Invention; capable of inhibiting the activity of SHP2. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the management of diseases or disorders associated with the aberrant activity of SHP2.

COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF SHP2

The present invention relates to compounds of formula I. The compounds are inhibitors of the Src Homolgy-2 phosphatase (SHP2) and thus useful in the treatment of Noonan Syndrome, Leopard Syndrome and cancer.

The design and discovery of novel amide CCR5 antagonists

The synthesis of a range of novel amine-containing structures and their primary potency as inhibitors of HIV-1 fusion via blocking of the CCR5 receptor is described. The development of the medicinal chemistry strategy and SAR's which led to the identification of the piperidine amide compounds 33 and 36 as excellent leads for further evaluation is described, along with key physicochemical data which highlighted their lead potential.