1464794-49-7

Basic information

• Product Name: (E)-2-(5-bromopyridin-3-yl)-5-(3,4,5-trimethoxystyryl)-1,3,4-oxadiazole
• CAS NO: 1464794-49-7
• Molecular Weight: 418.247
• Mol File: 1464794-49-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (E)-2-(5-bromopyridin-3-yl)-5-(3,4,5-trimethoxystyryl)-1,3,4-oxadiazole(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-2-(5-bromopyridin-3-yl)-5-(3,4,5-trimethoxystyryl)-1,3,4-oxadiazole(1464794-49-7)
• EPA Substance Registry System: (E)-2-(5-bromopyridin-3-yl)-5-(3,4,5-trimethoxystyryl)-1,3,4-oxadiazole(1464794-49-7)

Safety Data

• Hazardous Substances Data: 1464794-49-7(Hazardous Substances Data)

Upstream product

• 112193-41-6 5-bromonicotinic acid hydrazide 
• 20329-98-0 (E)-3,4,5-trimethoxy-cinnamic acid 
• 20986-40-7 ethyl 5-bromo-3-pyridinecarboxylate 
• 20826-04-4 5-bromo-3-pyridinecarboxylic acid 

Relevant articles and documents

Synthesis, biologicalevaluation, and molecular modeling of (E)-2-aryl-5-styryl-1,3,4-oxadiazolederivatives as acetylcholine esterase inhibitors

A library of 2,5-disubstituted 1,3,4-oxadiazole derivatives of (E)-2-aryl-5-(3,4,5-trimethoxystyryl)-1,3,4-oxadiazoles 4(a-o) and (E)-2-aryl-5-(2-benzo[d][1,3]dioxol-5-yl)vinyl)-1,3,4-oxadiazoles 5(a-q) were synthesized and evaluated for their in vitro acetylcholinesterase (AChE) inhibitory activity. All the synthesized compounds exhibited moderate to good inhibitory activity toward the AChE enzyme. Among the oxadiazole derivatives examined, compounds 4a, 4g, 5c, and 5m (IC50 values of 24.89, 13.72, 37.65, and 19.63 μM, respectively) were found to be promising inhibitors of AChE. Molecular protein-ligand docking studies were examined for these compounds using GOLD docking software and their binding conformations were determined and the simultaneous interactions mode was also established for the potent derivatives. Springer Science+Business Media 2013.