1465120-56-2

Basic information

• Product Name: C₁₅H₂₂BrNO₃S
• CAS NO: 1465120-56-2
• Molecular Weight: 376.315
• Mol File: 1465120-56-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₅H₂₂BrNO₃S(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₅H₂₂BrNO₃S(1465120-56-2)
• EPA Substance Registry System: C₁₅H₂₂BrNO₃S(1465120-56-2)

Safety Data

• Hazardous Substances Data: 1465120-56-2(Hazardous Substances Data)

Upstream product

• 115055-85-1 bromo-[(4-bromophenyl)methyl]zinc 

Relevant articles and documents

Radical migration-addition of N-tert-butanesulfinyl imines with organozinc reagents

A novel migration-addition sequence was discovered for the reaction of enantioenriched N-tert-butanesulfinyl iminoacetate 1a with functionalized benzylzinc bromide reagents, producing tert-leucine derivatives in excellent diastereoselectivity (dr 98:2). The absolute configurations of two new chiral centers were unambiguously assigned by chemical transformations and X-ray crystallography. In addition, the regio- and diastereoselectivities of this novel reaction were both explained through the key N-sulfinamine intermediate M6 generated by the tert-butyl radical attack on the imine. Computational analysis of this reaction process, which was performed at the B3LYP/6-311++G(3df,2p)//B3LYP/6-31G-LANL2DZ level, also supported our proposed two-stage mechanism.