146653-56-7 Usage
Description
2-(4-CYANOPHENYL)-3'-TRIFLUOROMETHYLACETOPHENONE is an organic compound with the molecular formula C17H11F3NO. It is characterized by its aromatic structure, featuring a phenyl ring with a cyano group at the para position and a trifluoromethyl group at the meta position. 2-(4-CYANOPHENYL)-3'-TRIFLUOROMETHYLACETOPHENONE is known for its unique chemical properties and potential applications in various industries.
Uses
Used in Pharmaceutical Industry:
2-(4-CYANOPHENYL)-3'-TRIFLUOROMETHYLACETOPHENONE is used as an intermediate compound for the synthesis of various pharmaceuticals. Its unique structure allows it to be a key component in the development of new drugs, particularly those targeting specific receptors or enzymes in the body.
Used in Chemical Research:
In the field of chemical research, 2-(4-CYANOPHENYL)-3'-TRIFLUOROMETHYLACETOPHENONE serves as a valuable compound for studying the properties and reactivity of aromatic systems. Its distinct functional groups make it an interesting subject for exploring various chemical reactions and mechanisms.
Used in Agrochemical Industry:
2-(4-CYANOPHENYL)-3'-TRIFLUOROMETHYLACETOPHENONE is used as a precursor in the development of agrochemicals, specifically insecticides. Its structure can be modified to create compounds that target specific pests, providing an effective means of controlling agricultural threats.
For example, Metaflumizone (M225825) is a semicarbazone insecticide derived from compounds like 2-(4-CYANOPHENYL)-3'-TRIFLUOROMETHYLACETOPHENONE. It works by blocking sodium channels in target insects, resulting in paralysis and the eventual death of the insect. Metaflumizone is particularly useful as a heartworm control treatment, protecting animals from the harmful effects of this parasitic disease.
Check Digit Verification of cas no
The CAS Registry Mumber 146653-56-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,6,6,5 and 3 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 146653-56:
(8*1)+(7*4)+(6*6)+(5*6)+(4*5)+(3*3)+(2*5)+(1*6)=147
147 % 10 = 7
So 146653-56-7 is a valid CAS Registry Number.
InChI:InChI=1/C16H10F3NO/c17-16(18,19)14-3-1-2-13(9-14)15(21)8-11-4-6-12(10-20)7-5-11/h1-7,9H,8H2
146653-56-7Relevant articles and documents
Benzylic Aroylation of Toluenes Mediated by a LiN(SiMe3)2/Cs+System
Gu, Yuanyun,Zhang, Zhen,Wang, Yan-En,Dai, Ziteng,Yuan, Yaqi,Xiong, Dan,Li, Jie,Walsh, Patrick J.,Mao, Jianyou
supporting information, p. 406 - 418 (2022/01/14)
Chemoselective deprotonative functionalization of benzylic C-H bonds is challenging, because the arene ring contains multiple aromatic C(sp2)-H bonds, which can be competitively deprotonated and lead to selectivity issues. Recently it was found that bimetallic [MN(SiMe3)2 M = Li, Na]/Cs+ combinations exhibit excellent benzylic selectivity. Herein, is reported the first deprotonative addition of toluenes to Weinreb amides mediated by LiN(SiMe3)2/CsF for the synthesis of a diverse array of 2-arylacetophenones. Surprisingly, simple methyl benzoates also react with toluenes under similar conditions to form 2-arylacetophenones without double addition to give tertiary alcohol products. This finding greatly increases the practicality and impact of this chemistry. Some challenging substrates with respect to benzylic deprotonations, such as fluoro and methoxy substituted toluenes, are selectively transformed to 2-aryl acetophenones. The value of benzylic deprotonation of 3-fluorotoluene is demonstrated by the synthesis of a key intermediate in the preparation of Polmacoxib.
Synthesizing method of 1,2-phenylacetophenone and derivative thereof
-
, (2017/07/20)
The invention discloses a synthesizing method of 1,2-phenylacetophenone and a derivative thereof. The synthesizing method comprises the following steps: (1) by using a compound I as an initiating raw material, generating amidating reaction with N,O-disubs
