146669-14-9Relevant articles and documents
Synthesis of new liquid phase carriers for use in large scale oligonucleotide synthesis in solution
Woerl, Ralf,Koester, Hubert
, p. 2941 - 2956 (1999)
The synthesis of multifunctional symmetric primary amines 4 and 8 and the covalent binding of 5'-O-dimethoxytrityl-deoxynucleoside derivatives to their amino groups (compound 5 and 9) is described. Different strategies for dedimethoxytritylation including the use of strong acidic ion exchangers or protic acids and modified silica gels and/or gel permeation chromatography are developed. The resulting liquid phase carriers 6 and 10 are suitable for large scale oligonucleotide synthesis in solution using phosphoamidites and gel permeation chromatography for fast isolation of intermediates.
Bisphosphonate sequestering agents. Synthesis and preliminary evaluation for in vitro and in vivo uranium(VI) chelation
Sawicki, Marcin,Lecercle, Delphine,Grillon, Gerard,Le Gall, Beatrice,Serandour, Anne-Laure,Poncy, Jean-Luc,Bailly, Theodorine,Burgada, Ramon,Lecouvey, Marc,Challeix, Vincent,Leydier, Antoine,Pellet-Rostaing, Stephane,Ansoborlo, Eric,Taran, Frederic
experimental part, p. 2768 - 2777 (2009/04/06)
A library of bisphosphonate-based ligands was prepared using solution-phase parallel synthesis and tested for its uranium-binding properties. With the help of a screening method, based on a chromophoric complex displacement procedure, 23 dipodal and tripodal chelates bearing bisphosphonate chelating functions were found to display very high affinity for the uranyl ion and were selected for evaluation of their in vivo uranyl-removal efficacy. Among them, 11 ligands induced a huge modification of the uranyl biodistribution by deviating the metal from kidney and bones to liver. Among the other ligands, the most potent was the dipodal bisphosphonate 3C which reduced the retention of uranyl and increased its excretion by around 10% of the injected metal.
Supramolecular compounds from multiple ugi multicomponent macrocyclizations: Peptoid-based cryptands, cages, and cryptophanes
Rivera, Daniel G.,Wessjohann, Ludger A.
, p. 7122 - 7123 (2007/10/03)
The first 3-fold multicomponent macrocyclizations of trifunctional building blocks were developed to produce, in one pot, cryptands, cages, and cryptophanes with peptoid tethers carrying additional recognition motifs. The straightforward, efficient, and d