146714-63-8

Basic information

• Product Name: 4-(2-Methoxyphenyl)-N-2-pyridinyl-1-piperazineacetaMide
• Synonyms: 4-(2-Methoxyphenyl)-N-2-pyridinyl-1-piperazineacetaMide;2-(4-(2-Methoxyphenyl)piperazin-1-yl) -N-(pyridin-2-yl)acetaMide
• CAS NO: 146714-63-8
• Molecular Formula: C₁₈H₂₂N₄O₂
• Molecular Weight: 326.39288
• Product Categories: Amines;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 146714-63-8.mol
• Article Data: 13

Chemical Properties

• Appearance: /
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility: DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 4-(2-Methoxyphenyl)-N-2-pyridinyl-1-piperazineacetaMide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-Methoxyphenyl)-N-2-pyridinyl-1-piperazineacetaMide(146714-63-8)
• EPA Substance Registry System: 4-(2-Methoxyphenyl)-N-2-pyridinyl-1-piperazineacetaMide(146714-63-8)

Safety Data

• Hazardous Substances Data: 146714-63-8(Hazardous Substances Data)

Usage

Description

4-(2-Methoxyphenyl)-N-2-pyridinyl-1-piperazineacetamide is an organic compound with a light brown solid appearance. It is a key component in the synthesis of WAY 100635 (W49865), which is a selective antagonist for the dopamine D4 receptor. 4-(2-Methoxyphenyl)-N-2-pyridinyl-1-piperazineacetaMide plays a significant role in the development of pharmaceuticals targeting the dopaminergic system.

Uses

Used in Pharmaceutical Industry:
4-(2-Methoxyphenyl)-N-2-pyridinyl-1-piperazineacetamide is used as an intermediate compound for the preparation of WAY 100635 (W49865), a selective dopamine D4 receptor antagonist. This application is crucial for the development of medications aimed at treating various neurological and psychiatric disorders, such as schizophrenia, attention deficit hyperactivity disorder (ADHD), and other conditions related to dopamine dysregulation.
Additionally, due to its interaction with the dopaminergic system, this compound may also be utilized in research and development for potential applications in the treatment of addiction, Parkinson's disease, and other dopamine-related conditions.

Upstream product

• 35386-24-4 1-(2-Methoxyphenyl)piperazine 
• 929039-11-2 chloro-acetic acid-[2]pyridylamide; hydrochloride 
• 504-29-0 2-aminopyridine 
• 5221-37-4 2-chloro-N-pyridin-2-ylacetamide 

Downstream Products

• 1421268-53-2 (1s,4s)-4-((2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)(pyridin-2-yl)carbamoyl)cyclohexanecarboxylic acid 
• 943976-22-5 (1r,4r)-4-(fluoromethyl)-N-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-N-(pyridin-2-yl)cyclohexanecarboxamide 
• 1421268-46-3 (1r,4r)-4-((2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)(pyridin-2-yl)carbamoyl)cyclohexanecarboxylic acid 
• 1391870-71-5 N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridyl)-1-naphthalene-carboxamide 
• 1391870-70-4 N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridyl)-2-naphthalene-carboxamide 
• 946530-10-5 (1r,4r)-4-((2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)(pyridin-2-yl)carbamoyl)cyclohexylmethyl 4-methylbenzenesulfonate 
• 946530-07-0 (1r,4r)-4-(hydroxymethyl)-N-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-N-(pyridin-2-yl)cyclohexanecarboxamide 
• 946530-05-8 trans-N-2-{2-[4-(2-methoxy-phenyl)piperazinyl]ethyl}-N-(2-pyridyl)-N-(4-carboxymethylcyclohexane) carboxamide 
• 1299426-10-0 4-iodo-N-(2-(4-(2-hydroxyphenyl)piperazin-1-yl)ethyl)-N-(pyridin-2-yl)bicyclo[2.2.1]heptane-1-carboxamide 
• 905457-34-3 4-iodo-N-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-N-(pyridin-2-yl)bicyclo[2.2.1]heptane-1-carboxamide 
• 1299426-06-4 4-odo-N-(2-(4-(2-hydroxyphenyl)piperazin-1-yl)ethyl)-N-(pyridin-2-yl)cubyl-1-carboxamide 
• 905457-35-4 4-iodo-N-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-N-(pyridin-2-yl)cubyl-1-carboxamide 
• 1299426-08-6 4-iodo-N-(2-(4-(2-hydroxyphenyl)piperazin-1-yl)ethyl)-N-(pyridin-2-yl)bicyclo[ 2.2.2]octane-1-carboxamide 
• 905457-33-2 4-iodo-N-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-N-(pyridin-2-yl)bicyclo[ 2.2.2]octane-1-carboxamide 

Relevant articles and documents

Synthesis and evaluation of 4-(2'-methoxyphenyl)-1-[2'-[N-(2''- pyridinyl)-p-iodobenzamido]ethyl]piperazine (p-MPPI): A new iodinated 5- HT(1A) ligand [2]

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Structural Insights into 5-HT1A/D4 Selectivity of WAY-100635 Analogues: Molecular Modeling, Synthesis, and in Vitro Binding

The resurgence of interest in 5-HT1A receptors as a therapeutic target requires the existence of highly selective 5-HT1A ligands. To date, WAY-100635 has been the prototypical antagonist of these receptors. However, this compound als

NOVEL SYNTHESIS METHOD

The present invention relates to a method of making compounds having affinity for the 1 A subtype of the serotonin receptor, i.e. 5HT1A. The method of the present invention provides advantages over the known methods of synthesis. The compounds