146726-46-7

Basic information

• Product Name: 8-Azabicyclo[3.2.1]octane, 8-methyl-2-(3-methyl-1,2,4-oxadiazol-5-yl)-3-phenyl-, (1R,2R,3R,5S)-
• Synonyms: 3α-phenyl-2α-(3'-methyl-1,2,4-oxadiazole-5'-yl)tropane;(1R,2R,3R,5S)-8-Methyl-2-(3-methyl-[1,2,4]oxadiazol-5-yl)-3-phenyl-8-aza-bicyclo[3.2.1]octane;3α-phenyl-2α-(3'-methyl-1',2',4'-oxadiazol-5'-yl)tropane
• CAS NO: 146726-46-7
• Molecular Formula: C17H21N3O
• Molecular Weight: 283.373
• Mol File: 146726-46-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 426.7±55.0 °C(Predicted)
• Density: 1.143±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 8-Azabicyclo[3.2.1]octane, 8-methyl-2-(3-methyl-1,2,4-oxadiazol-5-yl)-3-phenyl-, (1R,2R,3R,5S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 8-Azabicyclo[3.2.1]octane, 8-methyl-2-(3-methyl-1,2,4-oxadiazol-5-yl)-3-phenyl-, (1R,2R,3R,5S)-(146726-46-7)
• EPA Substance Registry System: 8-Azabicyclo[3.2.1]octane, 8-methyl-2-(3-methyl-1,2,4-oxadiazol-5-yl)-3-phenyl-, (1R,2R,3R,5S)-(146726-46-7)

Safety Data

• Hazardous Substances Data: 146726-46-7(Hazardous Substances Data)

Upstream product

• 591-51-5 phenyllithium 

Downstream Products

• 184376-56-5 (1R)-3α-phenyltropane-2β-carboxylic acid methyl ester 
• 147059-95-8 RTI-4229-119 
• 146726-47-8 (1R)-3α-phenyl-2β-(3-methyl-[1,2,4]oxadiazole-5-yl)tropane 

Relevant articles and documents

3α-(4'-Substituted phenyl)tropane-2β-carboxylic acid methyl esters: Novel ligands with high affinity and selectivity at the dopamine transporter

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3-Aryl-2-(3'-substituted-1',2',4'-oxadiazol-5'-yl)tropane analogues of cocaine: Affinities at the cocaine binding site at the dopamine, serotonin, and norepinephrine transporters

Previous studies have shown that 3β-(substituted phenyl)tropan-2β- carboxylic acid esters possess high affinity for the cocaine binding site on the dopamine transporter both in vitro and in vivo and inhibit dopamine uptake in vitro. Since 1,2,4-oxadiazole