1467641-73-1Relevant articles and documents
Potent inhibition of norovirus by dipeptidyl α-hydroxyphosphonate transition state mimics
Mandadapu, Sivakoteswara Rao,Gunnam, Mallikarjuna Reddy,Galasiti Kankanamalage, Anushka C.,Uy, Roxanne Adeline Z.,Alliston, Kevin R.,Lushington, Gerald H.,Kim, Yunjeong,Chang, Kyeong-Ok,Groutas, William C.
, p. 5941 - 5944 (2013/10/22)
The design, synthesis, and evaluation of a series of dipeptidyl α-hydroxyphosphonates is reported. The synthesized compounds displayed high anti-norovirus activity in a cell-based replicon system, as well as high enzyme selectivity.