1467739-15-6

Basic information

• Product Name: 1-(3-(2-amino-6-oxo-1,6-dihydropyrimidin-4-ylamino)-4-methylphenyl)-3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-urea
• Synonyms: 1-(3-(2-amino-6-oxo-1,6-dihydropyrimidin-4-ylamino)-4-methylphenyl)-3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-urea
• CAS NO: 1467739-15-6
• Molecular Weight: 408.417
• Mol File: 1467739-15-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(3-(2-amino-6-oxo-1,6-dihydropyrimidin-4-ylamino)-4-methylphenyl)-3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-urea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-(2-amino-6-oxo-1,6-dihydropyrimidin-4-ylamino)-4-methylphenyl)-3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-urea(1467739-15-6)
• EPA Substance Registry System: 1-(3-(2-amino-6-oxo-1,6-dihydropyrimidin-4-ylamino)-4-methylphenyl)-3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-urea(1467739-15-6)

Safety Data

• Hazardous Substances Data: 1467739-15-6(Hazardous Substances Data)

Upstream product

• 99-55-8 2-methyl-5-nitroaniline 
• 1467739-26-9 2-amino-6-(5-amino-2-methylphenylamino)pyrimidin-4(3H)-one 
• 100275-94-3 6-isocyanato-2,3-dihydrobenzo[b][1,4]dioxine 
• 1467739-25-8 2-amino-6-(2-methyl-5-nitrophenylamino)pyrimidin-4(3H)-one 

Relevant articles and documents

Synthesis of new pyrimidinylaminobenzene derivatives and their antiproliferative activities against melanoma cell line

A series of new diarylamide and diarylurea derivatives possessing pyrimidinylaminobenzene scaffold was synthesized. Their in vitro antiproliferative activities were tested against A375P human melanoma cell line. Among them, compounds 1a-c, k and 2b-d, f, g, j, l showed superior potencies against A375P human melanoma cell line to Sorafenib. In particular, compound 2f possessing 3-fluoro-5-trifluoromethyl moiety exhibited the highest potency with IC50 value in nanomolar scale.