146801-16-3

Basic information

• Product Name: 6,6,6-trifluoro-5-hydroxy-2,2-dimethyl-5-phenylhexan-3-one
• CAS NO: 146801-16-3
• Molecular Formula: C₁₄H₁₇F₃O₂
• Molecular Weight: 274.2788
• Mol File: 146801-16-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 337.5°C at 760 mmHg
• Flash Point: 157.9°C
• Density: 1.176g/cm³
• Vapor Pressure: 4.08E-05mmHg at 25°C
• Refractive Index: 1.47
• CAS DataBase Reference: 6,6,6-trifluoro-5-hydroxy-2,2-dimethyl-5-phenylhexan-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6,6,6-trifluoro-5-hydroxy-2,2-dimethyl-5-phenylhexan-3-one(146801-16-3)
• EPA Substance Registry System: 6,6,6-trifluoro-5-hydroxy-2,2-dimethyl-5-phenylhexan-3-one(146801-16-3)

Safety Data

• Hazardous Substances Data: 146801-16-3(Hazardous Substances Data)

Upstream product

• 75-97-8 3,3-dimethyl-butan-2-one 
• 434-45-7 2,2,2-Trifluoroacetophenone 

Relevant articles and documents

Aldol Reactions of Ketone Donors with Aryl Trifluoromethyl Ketone Acceptors Catalyzed by 1,8-Diazabicyclo[5.4.0]undec-7-ene (DBU) for Concise Access to Aryl- and Trifluoromethyl- Substituted Tertiary Alcohols

Molecules bearing aryl- and trifluoromethyl-substituted tertiary alcohol moieties are important as bioactive molecules, enantiomer-discriminating reagents, and their synthons and building blocks. To concisely synthesize these molecules, we have developed

KETONE-KETONE CONDENSATION WITH THE PARTICIPATION OF POLYHALOALKYL PHENYL KETONES

In the cross condensation of polyhaloalkyl phenyl ketones with methyl ketones in the presence of (ethylphenylamino)magnesium or (diethylamino)magnesium bromide or lithium hydride β-hydroxy ketones are formed, and the dehydration of these under the action