147212-86-0

Basic information

• Product Name: 4-Amino-1-(2’,3’,5’-tri-O-tert-butyldimethylsilyl--D-ribofuranosyl)-imidazo[4,5-a]pyridine
• Synonyms: 4-Amino-1-(2’,3’,5’-tri-O-tert-butyldimethylsilyl--D-ribofuranosyl)-imidazo[4,5-a]pyridine;4-Amino-1-(2',3',5'-tri-O-tert-butyldimethylsilyl-b-D-ribofuranosyl)-imidazo[4,5-c]pyridine;1-[2,3,5-Tris-O-[(1,1-diMethylethyl)diMethylsilyl]-β-D-ribofuranosyl]-1H-iMidazo[4,5-c]pyridin-4-aMine
• CAS NO: 147212-86-0
• Molecular Formula: C₂₉H₅₆N₄O₄Si₃
• Molecular Weight: 609.03584
• Product Categories: Bases & Related Reagents;Inhibitors;Nucleotides;Amines;Amines, Nucleotides, Bases & Related Reagents, Inhibitors
• Mol File: 147212-86-0.mol
• Article Data: 3

Chemical Properties

• Melting Point: 121-125°C
• Boiling Point: 595.676 °C at 760 mmHg
• Flash Point: 314.054 °C
• Appearance: /
• Density: 1.056 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.509
• Solubility: Chloroform, Ethyl Acetate
• PKA: 7.86±0.30(Predicted)
• CAS DataBase Reference: 4-Amino-1-(2’,3’,5’-tri-O-tert-butyldimethylsilyl--D-ribofuranosyl)-imidazo[4,5-a]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Amino-1-(2’,3’,5’-tri-O-tert-butyldimethylsilyl--D-ribofuranosyl)-imidazo[4,5-a]pyridine(147212-86-0)
• EPA Substance Registry System: 4-Amino-1-(2’,3’,5’-tri-O-tert-butyldimethylsilyl--D-ribofuranosyl)-imidazo[4,5-a]pyridine(147212-86-0)

Safety Data

• Hazardous Substances Data: 147212-86-0(Hazardous Substances Data)

Usage

Chemical Properties

Off-White Solid

InChI:InChI=1/C29H56N4O4Si3/c1-27(2,3)38(10,11)34-18-21-23(36-39(12,13)28(4,5)6)24(37-40(14,15)29(7,8)9)26(35-21)33-19-32-22-20(33)16-17-31-25(22)30/h16-17,19,21,23-24,26H,18H2,1-15H3,(H2,30,31)/t21-,23+,24+,26-/m1/s1

Upstream product

• 126004-13-5 5-ethynyl-1-β-D-ribofuranosylimidazole-4-carbonitrile 
• 300853-86-5 5-amino-1-[2',3',5'-O-tris(tert-butyldimethylsilyl)-β-D-ribofuranosyl]imidazole-4-carboxamide 
• 58-63-9 Inosine 
• 110526-62-0 2',3',5'-tris-O-(tert-butyldimethylsilyl)-2'-deoxyinosine 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 886227-18-5 2',3',5'-O-tris(tert-butyldimethylsilyl)-1-(2,4-dinitrophenyl)inosine 
• 886227-19-6 5-amino-1-[2',3',5'-O-tris(tert-butyldimethylsilyl)-β-D-ribofuranosyl]imidazole-4-carbonitrile 
• 886227-20-9 5-iodo-1-[2',3',5'-O-tris(tert-butyldimethylsilyl)-β-D-ribofuranosyl]imidazole-4-carbonitrile 
• 1066-54-2 trimethylsilylacetylene 
• 147212-83-7 5-ethynyl-1-(2,3,5-tri-O-tert-butyldimethylsilyl-β-D-ribofuranosyl)imidazole-4-carbonitrile 

Downstream Products

• 143354-17-0 2'-deoxy-N⁶-benzoyl-3-deazaadenosine 
• 176049-51-7 N-benzoyl-1-(beta-D-ribofuranosyl)-1H-imidazo[4,5-c]pyridin-4-amine 
• 886227-26-5 3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2'-deoxy-N⁶-benzoyl-3-deazaadenosine 
• 886227-24-3 3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-N⁶-benzoyl-3-deazaadenosine 
• 143556-17-6 5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-N⁶-benzoyl-3-deazaadenosine 
• 886227-25-4 3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2'-O-[(imidazol-1-yl)thiocarbonyl]-N⁶-benzoyl-3-deazaadenosine 
• 176049-52-8 5'-O-(4,4'-dimethoxytrityl)-N⁶-benzoyl-3-deazaadenosine 
• 886227-21-0 2'-O-triisopropylsilyl-5'-O-(4,4'-dimethoxytrityl)-N⁶-benzoyl-3-deazaadenosine 
• 666257-76-7 2'-deoxy-3'-O-[(N,N-diisopropylamino)-(β-cyanoethoxy)phosphino]-5'-O-(4,4'-dimethoxytrityl)-N⁶-benzoyl-3-deazaadenosine 
• 163152-53-2 3-chloro-3-deazaadenosine 

Relevant articles and documents

Efficient ribosomal peptidyl transfer critically relies on the presence of the ribose 2′-OH at A2451 of 23S rRNA

The ribosomal peptidyl transferase center is a ribozyme catalyzing peptide bond synthesis in all organisms. We applied a novel modified nucleoside interference approach to identify functional groups at 9 universally conserved active site residues. Owing t

Nucleosides and nucleotides. 114. A convenient method for the synthesis of 3-deazapurine nucleosides from AICA-riboside

3-Deazapurine nucleosides, 3-deazaguanosine (6) 3-deazaguanosine (12) and 3-deazaadenosine (17), were synthesized from 5-ethynyl-1- β-D-ribofuranosylimidazole-4-carboxamide (2) or -4-carbonitrile (13), which were readily obtained from AICA-riboside, via intramolecular ring closure.