147245-92-9 Usage
Description
Source:
Glatiramer acetate is a synthetic compound, and its production involves the polymerization of the mentioned amino acids in a specific molar ratio.
Production Methods:
The synthesis of glatiramer acetate involves the random copolymerization of L-alanine, L-lysine, l-glutamic acid, and L-tyrosine using standard polymerization techniques. The resulting copolymer is then purified and characterized to ensure its quality and consistency.
Uses
Used in Pharmaceutical Industry:
Glatiramer acetate is used as an immunomodulator for the treatment of multiple sclerosis (MS). It functions by modulating the immune system's response to myelin basic protein, which is a component of the myelin sheath that insulates nerve fibers. By altering the immune response, glatiramer acetate helps reduce the frequency and severity of MS relapses.
Used in Multiple Sclerosis Treatment:
Glatiramer acetate is used as a therapeutic agent for patients with relapsing-remitting multiple sclerosis (RRMS). It is administered through subcutaneous injections and has been shown to decrease the number of relapses and slow the progression of physical disability in RRMS patients.
Brand Name:
Copaxone (Teva) is the brand name under which glatiramer acetate is marketed. It is available in pre-filled syringes and auto-injectors for the convenience of patients and healthcare providers.
Originator
Copaxone,Teva Pharmaceuticals,Israel
Manufacturing Process
Glatiramer Acetate is water soluble copolypeptide with molecular weight
15,000-25,000.
Copolymer is prepared by copolymerization of the N-carboxyanhydrides of
tyrosine, alanine, lysine, and glutamic acid. The polymerisation was carried
out at ambient temperature in anhydrous dioxane with diethylamine as
initiator. Glatiramer Acetate have the ratio alanin:glutamic acid:lysine:tyrosine
= 1:6:4.54:2.
Clinical Use
Immunomodulating drug:
Treatment for patients at a high risk of developing
multiple sclerosis and for reduction in relapses in
ambulatory patients
Drug interactions
Potentially hazardous interactions with other drugs
None known
Metabolism
A substantial fraction of a subcutaneous dose of
glatiramer is believed to be hydrolysed locally. Some of
the injected dose is also presumed to enter the lymphatic
system, either intact or partially hydrolysed.
Check Digit Verification of cas no
The CAS Registry Mumber 147245-92-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,7,2,4 and 5 respectively; the second part has 2 digits, 9 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 147245-92:
(8*1)+(7*4)+(6*7)+(5*2)+(4*4)+(3*5)+(2*9)+(1*2)=139
139 % 10 = 9
So 147245-92-9 is a valid CAS Registry Number.
InChI:InChI=1/C9H11NO3.C6H14N2O2.C5H9NO4.C3H7NO2.C2H4O2/c10-8(9(12)13)5-6-1-3-7(11)4-2-6;7-4-2-1-3-5(8)6(9)10;6-3(5(9)10)1-2-4(7)8;1-2(4)3(5)6;1-2(3)4/h1-4,8,11H,5,10H2,(H,12,13);5H,1-4,7-8H2,(H,9,10);3H,1-2,6H2,(H,7,8)(H,9,10);2H,4H2,1H3,(H,5,6);1H3,(H,3,4)/t8-;5-;3-;2-;/m0000./s1