147384-01-8

Basic information

• Product Name: (S)-(+)-2-acetoxy-2-(4-methoxyphenyl)acetonitrile
• Synonyms: (S)-(+)-2-acetoxy-2-(4-methoxyphenyl)acetonitrile
• CAS NO: 147384-01-8
• Molecular Weight: 205.213
• Mol File: 147384-01-8.mol
• Article Data: 37

Chemical Properties

• CAS DataBase Reference: (S)-(+)-2-acetoxy-2-(4-methoxyphenyl)acetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-(+)-2-acetoxy-2-(4-methoxyphenyl)acetonitrile(147384-01-8)
• EPA Substance Registry System: (S)-(+)-2-acetoxy-2-(4-methoxyphenyl)acetonitrile(147384-01-8)

Safety Data

• Hazardous Substances Data: 147384-01-8(Hazardous Substances Data)

Upstream product

• 7677-24-9 trimethylsilyl cyanide 
• 108-24-7 acetic anhydride 
• 123-11-5 4-methoxy-benzaldehyde 
• 108-05-4 vinyl acetate 
• 33646-40-1 4-methoxymandelonitrile 
• 66985-48-6 2-(4-methoxyphenyl)-2-(trimethylsilyloxy)acetonitrile 
• 773837-37-9 sodium cyanide 
• 99843-19-3 acetoxy-(4-methoxy-phenyl)-acetonitrile 
• 631-57-2 Acetyl cyanide 
• 33646-40-1 (S)-4-methoxymandelonitrile 
• 75-36-5 acetyl chloride 
• 123-20-6 vinyl n-butyrate 
• 151-50-8 potassium cyanide 
• 447-61-0 2-Trifluoromethylbenzaldehyde 

Downstream Products

• 1015447-05-8 C₁₅H₁₅NO₃ 

Relevant articles and documents

Topology-Based Functionalization of Robust Chiral Zr-Based Metal-Organic Frameworks for Catalytic Enantioselective Hydrogenation

The design and development of robust and porous supported catalysts with high activity and selectivity is extremely significant but very challenging for eco-friendly synthesis of fine chemicals and pharmaceuticals. We report here the design and synthesis of highly stable chiral Zr(IV)-based MOFs with different topologies to support Ir complexes and demonstrate their network structures-dependent asymmetric catalytic performance. Guided by the modulated synthesis and isoreticular expansion strategy, five chiral Zr-MOFs with a flu or ith topology are constructed from enantiopure 1,1′-biphenol-derived tetracarboxylate linkers and Zr6, Zr9, or Zr12 clusters. The obtained MOFs all show high chemical stability in boiling water, strongly acidic, and weakly basic aqueous solutions. The two flu MOFs featuring the dihydroxyl groups of biphenol in open and large cages, after sequential postsynthetic modification with P(NMe2)3 and [Ir(COD)Cl]2, can be highly efficient and recyclable heterogeneous catalysts for hydrogenation of α-dehydroamino acid esters with up to 98% ee, whereas the three ith MOFs featuring the dihydroxyl groups in small cages cannot be installed with P(NMe2)3 to support the Ir complex. Incorporation of Ir-phosphorus catalysts into Zr-MOFs leads to great enhancement of their chemical stability, durability, and even stereoselectivity. This work therefore not only advances Zr-MOFs as stable supports for labile metal catalysts for heterogeneous asymmetric catalysis but also provides a new insight into how highly active chiral centers can result due to the framework topology.

The first porphyrin-salen based chiral metal-organic framework for asymmetric cyanosilylation of aldehydes

The first porphyrin-salen based chiral metal-organic framework (ps-CMOF) constructed by judiciously incorporating metalloporphyrin and metallosalen struts into one MOF structure is reported, which can serve as an effective heterogeneous catalyst for the a

An orthogonal biocatalytic approach for the safe generation and use of HCN in a multistep continuous preparation of chiral O-acetylcyanohydrins

An enantioselective preparation of O-acetylcyanohydrins has been accomplished by a three-step telescoped continuous process. The modular components enabled an accurate control of two sequential biotransformations, safe handling of an in situ generated hazardous gas, and in-line stabilization of products. This method proved to be advantageous over the batch protocols in terms of reaction time (40 min vs 345 min) and ease of operation, opening up access to reactions which have often been neglected due to safety concerns.