1474-10-8Relevant articles and documents
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Florey,Ehrenstein
, p. 1331,1343 (1954)
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FACILE SYNTHESIS OF CORTICOSTEROIDS FROM 17-KETOSTEROIDS VIA 20-CYANO-21-CARBOXYLATES
Gumulka, Maria,Kurek, Alicja,Wicha, Jerzy
, p. 741 - 748 (2007/10/02)
Introduction of the dihydroxyacetone side chain at position 17 of steroidal skeleton via cyanocarbalkoxymethylidene derivatives is described.The latter compounds were obtained by condensation of corresponding 17-oxoandrostanes with ethyl cyanoacetate.Synthesis of 17α,21-dihydroxypregn-4-ene-3,20-dione 21-acetate (Reichstein's substance S acetate) is presented.Syntheses of model 17-deoxycorticosteroids from 17-cyanocarbalkoxymethylidene derivatives were carried out.