147438-30-0 Usage
Description
Everolimus Related Compound 3 is an impurity of Sirolimus (R124000), which is an immunosuppressant drug used to prevent rejection in organ transplantation. It is a chemical compound with a complex structure, specifically a (2S)?-1-?[2-?[(2R,?3R,?6S)?-?6-?[(2S,?3E,?5E,?7E,?9S,?11R)?-?2,?13-?Dimethoxy-?3,?9,?11-?trimethyl-?12-?oxo-?3,?5,?7-?tridecatrien-?1-?yl]?tetrahydro-?2-?hydroxy-?3-?methyl-?2H-?pyran-?2-?yl]?-?2-?oxoacetyl]?-?2-?piperidinecarboxylic Acid.
Uses
Used in Pharmaceutical Industry:
Everolimus Related Compound 3 is used as an impurity in the production of Sirolimus (R124000), an immunosuppressant drug. Its presence is significant as it can affect the efficacy and safety of the final drug product. The compound plays a role in the development and formulation of Sirolimus, ensuring that the drug meets the required standards for organ transplantation patients.
Used in Research and Development:
Everolimus Related Compound 3 is also used in research and development for the study of its properties and potential applications. This may include investigating its interactions with other compounds, its effects on biological systems, and its potential use in the development of new drugs or therapies. The compound's complex structure and its relationship with Sirolimus make it an interesting subject for scientific inquiry.
Check Digit Verification of cas no
The CAS Registry Mumber 147438-30-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,7,4,3 and 8 respectively; the second part has 2 digits, 3 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 147438-30:
(8*1)+(7*4)+(6*7)+(5*4)+(4*3)+(3*8)+(2*3)+(1*0)=140
140 % 10 = 0
So 147438-30-0 is a valid CAS Registry Number.
147438-30-0Relevant articles and documents
Total synthesis of rapamycin via a novel titanium-mediated aldol macrocyclization reaction
Hayward,Yohannes,Danishefsky
, p. 9345 - 9346 (2007/10/02)
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Degradation of rapamycin: Synthesis of a rapamycin derived fragment containing the tricarbonyl and triene sectors
Yohannes,Myers,Danishefsky
, p. 2075 - 2078 (2007/10/02)
A degradation of rapamycin involving retro-Michael and retro-aldol steps retrieves the entire C1-C27 subunit.
