147596-64-3

Basic information

• Product Name: 5-(4-Fluorphenyl)-3-methylen-4,5-dihydro-2(3H)-furanon
• Synonyms: 5-(4-Fluorphenyl)-3-methylen-4,5-dihydro-2(3H)-furanon
• CAS NO: 147596-64-3
• Molecular Weight: 192.19
• Mol File: 147596-64-3.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 5-(4-Fluorphenyl)-3-methylen-4,5-dihydro-2(3H)-furanon(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-Fluorphenyl)-3-methylen-4,5-dihydro-2(3H)-furanon(147596-64-3)
• EPA Substance Registry System: 5-(4-Fluorphenyl)-3-methylen-4,5-dihydro-2(3H)-furanon(147596-64-3)

Safety Data

• Hazardous Substances Data: 147596-64-3(Hazardous Substances Data)

Upstream product

• 1000170-46-6 4-(4-fluoro-phenyl)-4-hydroxy-2-methylene-butyric acid 2,2,3,3,4,4,5,5,6,6,6-undecafluoro-hexyl ester 
• 459-57-4 4-fluorobenzaldehyde 
• 51787-96-3 5-(4-fluorophenyl)dihydrofuran-2(3H)-one 
• 147596-60-9 cis/trans-5-(4-Fluorphenyl)-2-oxo-4,5-dihydro-3H-furan-3-carbonsaeure 
• 17435-72-2 ethyl 2-bromomethyl-2-propenoate 

Downstream Products

• 148133-83-9 cis/trans-5-(4-Fluorphenyl)-3-(4-methylpiperidinomethyl)-4,5-dihydro-2(3H)-furanon-hydrochlorid 
• 148133-85-1 cis/trans-5-(4-Fluorphenyl)-3-<4-(2-oxo-1-benzimidazolinyl)-piperidinomethyl>-4,5-dihydro-2(3H)-furanon 
• 148133-87-3 cis/trans-3-<4-(4-Chlorphenyl)-4-hydroxy-piperidinomethyl>-5-(4-fluorphenyl)-4,5-dihydro-2(3H)-furanon-hydrochlorid 

Relevant articles and documents

Isatin Derived Spirocyclic Analogues with α-Methylene-γ-butyrolactone as Anticancer Agents: A Structure-Activity Relationship Study

Design, synthesis, and evaluation of α-methylene-γ-butyrolactone analogues and their evaluation as anticancer agents is described. SAR identified a spirocyclic analogue 19 that inhibited TNFα-induced NF-?°B activity, cancer cell growth and tumor growth in an ovarian cancer model. A second iteration of synthesis and screening identified 29 which inhibited cancer cell growth with low-?M potency. Our data suggest that an isatin-derived spirocyclic α-methylene-γ-butyrolactone is a suitable core for optimization to identify novel anticancer agents.

Fluorous tagging: An enabling isolation technique for indium-mediated allylation reactions in water

An efficient method was developed to allylate aldehydes using an aqueous indium-mediated allylation reaction with fluorous-tagged allyl halides, and to directly purify the products by fluorous solid phase extraction (F-SPE). The Royal Society of Chemistry

An improved procedure for α-methylenation of lactones

A variety of γ-butyrolactones, as well as a δ-valerolactone and an ester, have been efficiently converted to their α-methylene derivatives by using an improved decarboxylative methylenation procedure, which is simpler and more general than the previously