14764-32-0Relevant articles and documents
Preparation method of key intermediate 2-ethyl butyraldehyde of 2-ethyl butyric acid
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Paragraph 0013-0015, (2017/07/19)
The invention provides a preparation method of a key intermediate, 2-ethyl butyraldehyde, of 2-ethyl butyric acid, wherein the preparation method includes the steps of: adding an ethyl magnesium halide Grignard reagent to a protected alpha-halogenated aldehyde (I) solution, and performing a stirring reaction for 1-10 h at a certain temperature; performing post-treatment and de-protecting the product to obtain the 2-ethyl butyraldehyde. A route in the process in represented as follows. The method has short route and high usage ratio, is low in cost and easy to industrialize, and avoids defects in conventional methods.