147716-03-8 Usage
Description
1-METHYL-5-TRIBUTYLSTANNANYL-1H-IMIDAZOLE is an organic compound with the chemical structure featuring a methyl group, a tri-n-butylstannyl group, and an imidazole ring. It is known for its unique properties and potential applications in various fields due to its chemical composition and reactivity.
Uses
Used in Pharmaceutical Applications:
1-METHYL-5-TRIBUTYLSTANNANYL-1H-IMIDAZOLE is used as a pharmaceutical compound for its potential therapeutic effects. Its unique chemical structure allows it to interact with biological targets, making it a promising candidate for the development of new drugs.
Used in Drug Candidates:
1-METHYL-5-TRIBUTYLSTANNANYL-1H-IMIDAZOLE is utilized as a drug candidate due to its ability to modulate biological processes and target specific receptors or enzymes. Its chemical properties make it a valuable starting point for the design and synthesis of novel therapeutic agents.
Used as Ligands for Transition Metal Catalysts:
1-METHYL-5-TRIBUTYLSTANNANYL-1H-IMIDAZOLE serves as a ligand in the field of catalysis, particularly for transition metal catalysts. Its stannyl group and imidazole ring contribute to its ability to form stable complexes with metal centers, enhancing the catalyst's performance in various chemical reactions.
Used in Molecular Functional Materials:
1-METHYL-5-TRIBUTYLSTANNANYL-1H-IMIDAZOLE is also employed in the development of molecular functional materials, where its unique properties can be harnessed for applications such as sensors, optoelectronic devices, and energy storage systems. Its versatility in chemical reactivity and structural diversity makes it a valuable component in the design of advanced materials.
Check Digit Verification of cas no
The CAS Registry Mumber 147716-03-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,7,7,1 and 6 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 147716-03:
(8*1)+(7*4)+(6*7)+(5*7)+(4*1)+(3*6)+(2*0)+(1*3)=138
138 % 10 = 8
So 147716-03-8 is a valid CAS Registry Number.
InChI:InChI=1/C4H5N2.3C4H9.Sn/c1-6-3-2-5-4-6;3*1-3-4-2;/h2,4H,1H3;3*1,3-4H2,2H3;/rC16H32N2Sn/c1-5-8-11-19(12-9-6-2,13-10-7-3)16-14-17-15-18(16)4/h14-15H,5-13H2,1-4H3
147716-03-8Relevant articles and documents
p27 PROTEIN INDUCER
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Paragraph 1120-1123, (2016/10/08)
The present invention provides a p27 protein inducing agent comprising a compound represented by general formula (11) below or pharmaceutically acceptable salt thereof as an active ingredient: wherein G 1 , G 2 , G 3 and G 8 are each independently selected from -N= etc., Ring G 6 is selected from divalent aryl etc., A is selected from amino etc., G 4 is selected from oxygen etc., G 5 is selected from oxygen etc., G 7 is selected from -CH 2 - etc., and R 2 is selected from C 1-6 alkyl etc.
3-‘4-HETEROCYCLYL -1,2,3,-TRIAZOL-1-YL!-N-ARYL-BENZAMIDES AS INHIBITORS OF THE CYTOKINES PRODUCTION FOR THE TREATMENT OF CHRONIC INFLAMMATORY DISEASES
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Page/Page column 91, (2008/06/13)
Disclosed compounds of formula (I), which inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as chronic inflammatory disease. Also disclosed are processes for preparing these compounds and pharmaceutical compositions comprising these compounds.
Cross-coupling methods for the large-scale preparation of an imidazole - Thienopyridine: Synthesis of [2-(3-methyl-3H-imidazol-4-yl)-thieno[3,2-b]pyridin-7-yl] -(2-methyl-1H-indol-5-yl)-amine
Ragan,Raggon,Hill,Jones,McDermott,Munchhof,Marx,Casavant,Cooper,Doty,Lu
, p. 676 - 683 (2013/09/05)
The multihundred-gram synthesis of [2-(3-methyl-3H-imidazol-4-yl)-thieno[3,2-b]pyridin-7-yl] -(2-methyl-1H-indol-5-yl)-amine (1) is described utilizing a Stille cross-coupling of an iodothienopyridine (3) with 5-(tributylstannyl)-1-methylimidazole (11). Several cross-coupling methods were evaluated for the conversion of thienopyridine 3 to imidazole - thienopyridine 2, but only two were effective: the Stille coupling and a Negishi cross-coupling of the organozinc reagent derived from 2-(tertbutyldimethylsilyl)-1-methylimidazole and iodothienopyridine (3). The latter procedure worked well on laboratory scale (50 g), but was capricious upon scale-up. The issues with scale-up of an organostannane reagent are discussed, including control and analysis of organotin levels.
